| 產(chǎn)品編號(hào) | bsm-63020R |
| 英文名稱 | Phospho-VAV1 (Tyr174) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化鳥苷酸轉(zhuǎn)換因子VAV1重組兔單抗 |
| 別 名 | Oncogene vav; p95Vav; Proto-oncogene vav; VAV 1 oncogene; VAV; Vav proto oncogene; VAV1. |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,ICC/IF=1:50-1:200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 98 kDa |
| 檢測(cè)分子量 | 98 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human VAV1 around the phosphorylation site of Y174: GDEI-pY-EDL |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. SWISS: P15498 Gene ID: 7409 Vav1蛋白是特異于造血細(xì)胞表達(dá)的鳥苷酸轉(zhuǎn)換因子,它參與了多種免疫細(xì)胞如T細(xì)胞,B細(xì)胞,巨噬細(xì)胞,自然殺傷性細(xì)胞等的胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo),發(fā)揮著重要作用. Vav1主要參與T細(xì)胞信號(hào)傳導(dǎo)途徑，傳導(dǎo)信號(hào)激活鈣流、細(xì)胞外信號(hào)調(diào)節(jié)激酶（ERK）以及轉(zhuǎn)錄因子NFκB。Vav1蛋白在T細(xì)胞生長(zhǎng)發(fā)育、成熟T細(xì)胞激活、細(xì)胞因子合成及細(xì)胞骨架活動(dòng)中發(fā)揮重要作用。 |
