| 產(chǎn)品編號 | bs-1250R |
| 英文名稱 | Gax Rabbit pAb |
| 中文名稱 | 生長終止特異性同源盒基因抗體 |
| 別 名 | growth arrest-specific homeobox; Homeobox protein MOX-2; Mesenchyme homeobox 2; mesenchyme homeobox 2-like; Growth arrest-specific homeobox; GAX; growth arrest homeobox transcription factor GAX; mesenchyme homeobox 2; MEOX2_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 心血管 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 33 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Gax: 201-304/304 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimers disease. Function: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Subunit: Interacts with RNF10. Subcellular Location: Nucleus. Nucleus speckle. Similarity: Contains 1 homeobox DNA-binding domain. SWISS: P50222 Gene ID: 4223 Database links: Entrez Gene: 4223 Human Entrez Gene: 17286 Mouse Omim: 600535 Human SwissProt: P50222 Human SwissProt: P32443 Mouse Unigene: 170355 Human Unigene: 341398 Mouse Unigene: 34890 Rat Gax主要在血管平滑肌細(xì)胞和內(nèi)皮細(xì)胞中表達(dá)的同源異形盒基因,但Gax基因過表達(dá)可以抑制血管平滑肌細(xì)胞和內(nèi)皮細(xì)胞的增殖，Gax也是脊椎動物肢體發(fā)育的重要調(diào)節(jié)因子，目前除用于心血管方面的研究，也用于腫瘤血管方面的探索。 |
