| 產(chǎn)品編號(hào) | bs-1563R |
| 英文名稱 | E.coli O157:H7 Rabbit pAb |
| 中文名稱 | 腸出血性大腸桿菌埃希氏菌O157:H7抗體 |
| 別 名 | Escherichia coli O157:H7; Enterohemorrhage E.Coli; EHEC |
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Specific References (3) | bs-1563R has been referenced in 3 publications.
[IF=32.086] Zeying Zhang. et al. Rapid Identification and Monitoring of Multiple Bacterial Infections Using Printed Nanoarrays. ADV MATER. 2023 Jan;:2211363 Other ; Escherichia Coli.
[IF=6.45] Chen, Ze-Zhong, et al. "Indirect immunofluorescence detection of E. coli O157: H7 with fluorescent silica Nanoparticles." Biosensors and Bioelectronics (2014).
[IF=0.34] Xue, Haiyan, et al. "Rapid Immunochromatographic Assay for Escherichia coli O157: H7 in Bovine Milk Using IgY Labeled by Fe 3 O 4/Au Composite Nanoparticles." Food Science and Technology Research 22.1 (2016): 53-58. ELISA ;
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| 研究領(lǐng)域 | 免疫學(xué) 細(xì)菌及病毒 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | (predicted: Escherichia Coli) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | kDa |
| 檢測(cè)分子量 | |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Ecoli O157;H7 protein |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This antibody reacts with Escherichia coli O157 (E.coli O157), Escherichia coli is a gram negative bacillus that belongs to a larger group of Enterobacteriae - bacteria that inhabit the gastrointestinal tract. Although usually a harmless resident of the gut, some strains have the potential to cause serious problems, especially where there is an immature immune system or immunosuppression, or where the subtype of organism has acquired the ability to produce pathogenic toxins. Function: Escherichia coli are Gram negative bacterium that are commonly found in the lower intestine of warm-blooded organisms (endotherms). Their serological types are determined in combination with somatic antigens (O group: O1-O173) and flagella antigens (H type: H1-H56). The E. coli that cause intestinal infectious diseases including diarrhea, acute gastritis or colitis are referred to as pathogenic E. coli, which are classified into the following 4 groups according to differences in the mode of pathogenicity; enteropathogenic E. coli (EPEC), enteroinvasive E. coli (EIEC), enterotoxigenic E. coli (ETEC) and enterohemorrhagic E. coli (EHEC). Although the identification of pathogenic E. coli requires verification of their pathogenicity, pathogenic E. coli often have specific serotypes; therefore, typing of the serogroup and serotype is necessary in screening pathogenic E. coli. ????EHEC-腸出血性大腸埃希氏菌O157:H7(E.coli O157:H7)為產(chǎn)腸毒素大腸桿菌埃希氏菌-腸出血致病性大腸埃希氏菌的一種與志賀痢疾桿菌I型產(chǎn)生的毒素相似。 ????EHEC主要侵犯結(jié)腸，在腸道能使腸粘膜細(xì)胞壞死，引起組織病變-形成腸壁潰瘍； EHEC-大腸埃希氏菌O157：H7是毒力最強(qiáng)的一種，該毒株對(duì)很多抗菌素都有不同的耐、抗藥性，嚴(yán)重者，可導(dǎo)致溶血性尿毒綜合征癥狀,治療不及時(shí)會(huì)引起死亡。 ????EHEC引起腸道侵襲性病變，主要在結(jié)腸部位。研究認(rèn)為ETEC產(chǎn)生的志賀樣毒素與腸壁組織的微血管內(nèi)皮細(xì)胞上的受體結(jié)合，引起血管損傷，同時(shí)激發(fā)局部細(xì)胞因子TNF、LPS及IL1β增加。這些細(xì)胞因子又增強(qiáng)受體對(duì)毒素的敏感性，促使血管損傷進(jìn)一步加重。此毒素是否作用于其他臟器內(nèi)皮細(xì)胞，激發(fā)產(chǎn)生細(xì)胞因子，引起局部損傷-引起血管出血情況的現(xiàn)象有待進(jìn)一步研究。 |
