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CCL27 Rabbit pAb (bs-2484R)  
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產(chǎn)品編號(hào) bs-2484R
英文名稱 CCL27 Rabbit pAb
中文名稱 皮膚T細(xì)胞虜獲趨化因子抗體
別    名 ALP; CTACK; C-C motif chemokine 27; CC chemokine ILC; Ccl27; CTAK; Cutaneous T cell attracting chemokine; Cutaneous T-cell-attracting chemokine; ESkine; IL 11 R alpha locus chemokine; IL-11 R-alpha-locus chemokine; PESKY; SCYA27; Skinkine; Small inducible cytokine A27; Small-inducible cytokine A27.  
研究領(lǐng)域 免疫學(xué)  趨化因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Human (predicted: Mouse,Rat,Cow)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 19 kDa
檢測(cè)分子量
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse CCL27: 25-112/164 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq].

Function:
Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

Subunit:
Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.

Subcellular Location:
Secreted.

Tissue Specificity:
Testis, thymus, placenta, ovary and skin.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

SWISS:
Q9Z1X0

Gene ID:
20301

Database links:

Entrez Gene: 10850 Human

Omim: 604833 Human

SwissProt: Q5VZ77 Human

SwissProt: Q9Y4X3 Human

Unigene: 459590 Human

Unigene: 648124 Human



CCL27是一種CC型趨化因子,又被稱為Skinkine,ESkine和CTACK。CCL27基因位于人類染色體9,它與皮膚上歸巢的記憶T淋巴細(xì)胞有關(guān),并在T細(xì)胞介導(dǎo)的皮膚炎癥中起著重要的作用。CCL27表達(dá)在許多組織,包括性腺,胸腺,胎盤(pán)和皮膚。其配體為CCR10,CCL27與接觸性軟疣病毒編碼產(chǎn)生的蛋白質(zhì)MC148有較高的同源性,但卻與人皰疹病毒8型編碼產(chǎn)生病毒巨噬細(xì)胞炎癥蛋白-Ⅱ競(jìng)爭(zhēng)結(jié)合受體CCR10。
產(chǎn)品圖片
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CCL27 Polyclonal Antibody, Unconjugated(bs-2484R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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