| 產(chǎn)品編號(hào) | bs-2659R |
| 英文名稱 | MARCO Rabbit pAb |
| 中文名稱 | 巨噬細(xì)胞清道夫受體抗體 |
| 別 名 | Macrophage receptor MARCO; Marco; MARCO_HUMAN; Macrophage receptor with collagenous structure; SCARA2; Scavenger receptor class A member 2. |
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Specific References (2) | bs-2659R has been referenced in 2 publications.
[IF=12.57] Li, Hao, et al. "Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus." The Journal of clinical investigation 125.7 (2015): 2877. IHC-P ; Human.
[IF=3.329] Xiao Y et al. Down-regulation of MARCO associates with tumor progression in hepatocellular carcinoma. Exp Cell Res. 2019 Aug 2:111542. WB&IHC-P ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 微生物學(xué) 細(xì)菌及病毒 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human,Mouse,GuineaPig (predicted: Rat,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 53 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MARCO: 421-520/520 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq].
Function: Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria. Subunit: Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands. Subcellular Location: Membrane; Single-pass type II membrane protein. Similarity: Contains 1 collagen-like domain. Contains 1 SRCR domain. SWISS: Q9UEW3 Gene ID: 8685 Database links: Entrez Gene: 8685 Human Omim: 604870 Human SwissProt: Q9UEW3 Human Unigene: 67726 Human |
| 產(chǎn)品圖片 |
Tissue/cell: mouse lung tissue;4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-MARCO Polyclonal Antibody, Unconjugated(bs-2659R-FITC) 1:100, overnight at 4°C; DAPI(5ug/ml,blue,C-0033) was used to stain the cell nuclei
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