| 產(chǎn)品編號(hào) | bs-3347R |
| 英文名稱 | Rabbit Anti-Phospho-PRK1 (Thr774) + PRK2 (Thr816) + PRK3 (Thr718) antibody |
| 中文名稱 | 磷酸化內(nèi)分泌腺衍生血管內(nèi)皮生長(zhǎng)因子抗體 |
| 別 名 | PRK3+PRK2+PRK1 (phospho T816 + T718 + T774); PROK1; Prokineticin-1/Endocrine-gland-derived vascular endothelial growth factor; EGVEGF; PK1; EG-VEGF; EG VEGF; PRK1; Prokineticin 1; Black mamba toxin related; Endocrine gland derived vascular endothelial growth factor; Endocrine-gland-derived vascular endothelial growth factor; Mambakine; PROK1_HUMAN; Cardiolipin activated protein kinase Pak2; PAK 2; PAK2; PKN gamma; PKN2; PKN2_HUMAN; PRK2; PRKCL2; PRO2042; Protein kinase C like 2; Protein kinase C related kinase 2; Protein kinase C-like 2; Protein kinase N2; Protein-kinase C-related kinase 2; Serine/threonine-protein kinase N2. |
| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 血管內(nèi)皮細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 103kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human PRK1 around the phosphorylation site of Thr774: TS(p-T)FC |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011] Function: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. Subcellular Location: Secreted. Tissue Specificity: Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta. Similarity: Belongs to the AVIT (prokineticin) family. SWISS: P58294 Gene ID: 84432 Database links: Entrez Gene: 84432 Human Entrez Gene: 246691 Mouse Omim: 606233 Human SwissProt: P58294 Human SwissProt: Q14A28 Mouse Unigene: 514793 Human Unigene: 461353 Mouse Unigene: 82757 Rat EG-VEGF是先被發(fā)現(xiàn)的組織特異性促血管生成因子,與多種特定組織腫瘤的發(fā)生及演進(jìn)相關(guān)，EG-VEGF多在卵巢、睪丸、腎上腺、胎盤等類固醇合成組織中高表達(dá)。 |
