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CYP27A1 Rabbit pAb (bs-5049R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-5049R
英文名稱 CYP27A1 Rabbit pAb
中文名稱 膽固醇27α羥化酶抗體
別    名 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase; Cholestanetriol 26 monooxygenase; CP27; CTX; CYP; CYP27; Cytochrome P 450C27/25; Cytochrome P450 27; Cytochrome P450 27 mitochondrial; Cytochrome P450 family 27 subfamily A polypeptide 1; CP27A_HUMAN; Cytochrome P450 subfamily XXVIIA(steroid 27-hydroxylase cerebrotendinous xanthomatosis) polypeptide 1; Sterol 26 hydroxylase; Sterol 26 hydroxylase mitochondrial; Sterol 27 hydroxylase; Vitamin D(3) 25 hydroxylase.  
Specific References  (2)     |     bs-5049R has been referenced in 2 publications.
[IF=17.694] Tang Bo. et al. Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy. NAT COMMUN. 2023 Mar;14(1):1-17  IHC-P ;  Mouse.  
[IF=4.294] Yaochang Wei. et al. Targeted metabolomics analysis of bile acids and cell biology studies reveal the critical role of glycodeoxycholic acid in buffalo follicular atresia. J STEROID BIOCHEM. 2022 Jul;221:106115  IHC ;  Bovine.  
研究領域 腫瘤  心血管  細胞生物  免疫學  染色質和核信號  信號轉導  脂蛋白  新陳代謝  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat,Rabbit,Pig,Cow,Dog,Horse)
產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 57 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 線粒體
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CYP27A1: 321-420/531 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. [provided by RefSeq, Jul 2008].

Function:
Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.

Subcellular Location:
Mitochondrion membrane.

DISEASE:
Cerebrotendinous xanthomatosis (CTX) [MIM:213700]: Rare sterol storage disorder characterized clinically by progressive neurologic dysfunction, premature atherosclerosis, and cataracts. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the cytochrome P450 family.

SWISS:
Q02318

Gene ID:
1593

Database links:

Entrez Gene: 1593 Human

Entrez Gene: 104086 Mouse

Entrez Gene: 301517 Rat

Omim: 606530 Human

SwissProt: Q02318 Human

SwissProt: Q9DBG1 Mouse

SwissProt: P17178 Rat

Unigene: 516700 Human

Unigene: 85083 Mouse

Unigene: 94956 Rat



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