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MTTP Rabbit pAb (bs-5083R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5083R
英文名稱 MTTP Rabbit pAb
中文名稱 微粒體甘油三酯轉(zhuǎn)運(yùn)蛋白
別    名 ABL; Microsomal triglyceride transfer protein(large polypeptide 88kDa); Microsomal triglyceride transfer protein 88kD; Microsomal triglyceride transfer protein; Microsomal triglyceride transfer protein large subunit; MTP; MTP large subunit; MTP_HUMAN; MTTP; Transfer RNA, mitochondrial, proline; tRNA-Pro, mitochondrial; Microsomal triglyceride transfer protein large; Microsomal triglyceride transfer protein large Precursor; microsomal triglyceride transfer protein large subunit precursor.  
Specific References  (1)     |     bs-5083R has been referenced in 1 publications.
[IF=3.352] Rongxue Wei. et al. Study on the Effect of Different Types of Sugar on Lipid Deposition in Goose Fatty Liver. Poultry Sci. 2022 Jan;:101729  WB ;  Goose.  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  脂蛋白  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Rat (predicted: Human,Mouse,Rabbit,Pig,Cow,GuineaPig,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 97 kDa
檢測分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MTTP: 801-900/894 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 MTTP catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. MTTP is required for the secretion of plasma lipoproteins that contain apolipoprotein B. It is positively regulated by cholesterol and negatively regulated by insulin. Defects in MTP are the cause of abetalipoproteinemia.

Function:
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.

Subunit:
Heterodimer composed of MTTP and of protein disulfide isomerase (P4HB/PDI) (By similarity).

Subcellular Location:
Endoplasmic reticulum.

Tissue Specificity:
Liver and small intestine. Also found in ovary, testis and kidney.

DISEASE:
Abetalipoproteinemia (ABL) [MIM:200100]: An autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing lipoproteins (chylomicrons, VLDL, LDL, lipoprotein(A)). Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 1 vitellogenin domain.

SWISS:
P55157

Gene ID:
4547

Database links:

Entrez Gene: 487873 Dog

Entrez Gene: 100734244 Guinea pig

Entrez Gene: 100053803, Horse

Entrez Gene: 4547 Human

Entrez Gene: 17777 Mouse

Entrez Gene: 397381 Pig

Entrez Gene: 100341961 Rabbit

Entrez Gene: 310900 Rat

Omim: 590075 Human

SwissProt: P55156 Cow

SwissProt: P55157 Human

SwissProt: O08601 Mouse

SwissProt: Q865F1 Pig

Unigene: 195799 Human

Unigene: 2941 Mouse

Unigene: 81556 Rat



微粒體甘油三酯轉(zhuǎn)移蛋白(microsomal triglyceride transfer protein,MTP)是一種主要分布于肝細(xì)胞、腸上皮細(xì)胞中的脂質(zhì)轉(zhuǎn)移蛋白,存在于細(xì)胞微粒體、內(nèi)質(zhì)網(wǎng)腔內(nèi),在內(nèi)質(zhì)網(wǎng)內(nèi)含量最高,占總蛋白的0.5%-1.0%,MTTP在甘油三酯轉(zhuǎn)運(yùn)及極低密度脂蛋白組裝和分泌中發(fā)揮著重要作用。
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