日日操日日操,亚洲日本午夜激情,人妻内射精品一区二区,国产一区北条麻妃

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产精品欧美100,国产欧美日韩在线一,久久精品国产亚洲AV无码南京
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
SPTLC1 Rabbit pAb (bs-4087R)  
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-4087R
英文名稱 SPTLC1 Rabbit pAb
中文名稱 絲氨酸棕櫚酰轉(zhuǎn)移酶1抗體
別    名 HSAN; HSAN1; HSN1; LBC1; LCB 1; LCB1; Long chain base biosynthesis protein 1; Serine C palmitoyltransferase; Serine palmitoyl CoA transferase 1; Serine palmitoyltransferase 1; Serine palmitoyltransferase long chain base subunit 1; Serine palmitoyltransferase subunit 1; SPT 1; SPT1; SPTI; SPTLC 1; SPTC1_HUMAN.  
研究領(lǐng)域 腫瘤  心血管  免疫學(xué)  染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) (predicted: Human,Mouse,Rat,Pig,Cow,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 53 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPTLC1: 121-220/473 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. [provided by RefSeq, Jul 2013]

Function:
Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.

Subunit:
Heterodimer with SPTLC2 or SPTLC3. Component of the serine palmitoyltransferase (SPT) complex, composed of SPTLC1, either SPTLC2 or SPTLC3, and either SSSPTA or SSSPTB. Interacts with SPTSSA and SPTSSB; the interaction is direct. Interacts with ORMDL3.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass membrane protein

Tissue Specificity:
Widely expressed. Not detected in small intestine.

DISEASE:
Defects in SPTLC1 are the cause of hereditary sensory and autonomic neuropathy type 1A (HSAN1A) [MIM:162400]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN1A is an autosomal dominant axonal neuropathy with onset in the second or third decades. Initial symptoms are loss of pain, touch, heat, and cold sensation over the feet, followed by distal muscle wasting and weakness. Loss of pain sensation leads to chronic skin ulcers and distal amputations.

Similarity:
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

SWISS:
O15269

Gene ID:
10558

Database links:

Entrez Gene: 426145 Chicken

Entrez Gene: 739412 Chimpanzee

Entrez Gene: 614165 Cow

Entrez Gene: 100726468 Guinea pig

Entrez Gene: 10558 Human

Entrez Gene: 268656 Mouse

Entrez Gene: 100344536 Rabbit

Entrez Gene: 705324 Rhesus monkey

Omim: 605712 Human

SwissProt: Q3MHG1 Cow

SwissProt: Q60HD1 Cynomolgus Monkey

SwissProt: O15269 Human

SwissProt: O35704 Mouse

Unigene: 90458 Human

Unigene: 240336 Mouse



版權(quán)所有 2004-2026 m.bklrv.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
日本成人大片3区| 成人黄色免费AV| 173成人综合导航| 久久久久.998| 内射少妇16AV| 就去91大神在线第一页| 日本一区二区三区精品久久| 麻豆视频在线播放| 日韩一区二区激情视频| 草草影院一区二区| 最新无码人妻在线| 国产欧美综合 激情| 麻豆强制在线| 50岁熟妇骚逼一级毛片| 成人电影免费日韩| 欧美日韩在线资源视频观看| 国产精品丝袜脚交| 视频亚洲综合福利在线| 大香蕉美国| 日本中文字幕a√在綫| 丰满人妻熟女| 午夜性专场| 久久网站精选久| 欧美伊人久久综合熟女导航| 一青青草原在线一二区| 操B综合网视频| 在中文字幕在线资源| av一区免费看不卡| www.91福利视频| 夜夜激情影院| 四虎国产精品永久在线地址的介绍| 超碰97 人妻| 日韩乱伦欧美| 欧美国产日韩一区二区三级论理| 日韩美AV不卡久久| 激情婷婷AV综合| 殴美综合五月| 国产三级视频黄色| 少妇3p二区| 久久青春国产| 欧美一日韩一级|