| 產(chǎn)品編號 | bs-10071R |
| 英文名稱 | Rabbit Anti-VEGFB167 antibody |
| 中文名稱 | 血管內(nèi)皮生長因子B167 |
| 別 名 | VEGFB 167; VEGFB-167; Vascular endothelial growth factor B; VEGF B; VEGFB; VEGF-B; VEGF related factor; VEGFL; Vrf; vascular endothelial growth factor B isoform VEGFB-167 precursor; VEGFB_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 生長因子和激素 激酶和磷酸酶 細(xì)胞膜受體 血管內(nèi)皮細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse,Pig,Cow,GuineaPig,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 22kDa |
| 細(xì)胞定位 | 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human VEGFB isoform VEGFB-167: 121-188/188 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described and include fibroblast growth factor (FGF), platelet derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs). The VEGF protein family is comprised of VEGF, VEGF-B, VEGF-C and VEGF-D, all of which may exhibit angiogenic function in vivo. VEGF-B, which exists as two alternatively spliced isoforms known as VEGF-B167 and VEGF-B186, is abundantly expressed in heart and skeletal muscle and is frequently co-expressed with VEGF. VEGF-C binds to and specifically activates Flt-4 and Flk-1. Function: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. Subcellular Location: Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin. Tissue Specificity: Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. Post-translational modifications: VEGF-B167 is O-glycosylated. Similarity: Belongs to the PDGF/VEGF growth factor family. SWISS: P49765-2 Gene ID: 7423 Database links: Entrez Gene: 7423 Human Entrez Gene: 22340 Mouse Omim: 601398 Human SwissProt: P49765 Human SwissProt: P49766 Mouse Unigene: 78781 Human Unigene: 15607 Mouse Unigene: 198550 Rat |
| 產(chǎn)品圖片 |
Sample:
H9C2(Rat) Cell Lysate at 30 ug
Primary: Anti-VEGFB167 (bs-10071R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 22 kD
Observed band size: 21 kD
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