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VEGFB Rabbit pAb (bs-10072R)  
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產(chǎn)品編號 bs-10072R
英文名稱 VEGFB Rabbit pAb
中文名稱 血管內(nèi)皮生長因子B
別    名 Vascular endothelial growth factor B; VEGF B; VEGFB; VEGF-B; VEGF related factor; VEGFL; Vrf; vascular endothelial growth factor B isoform VEGFB-167 precursor; VEGFB_HUMAN.  
研究領(lǐng)域 腫瘤  細胞生物  神經(jīng)生物學  生長因子和激素  激酶和磷酸酶  細胞膜受體  血管內(nèi)皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Pig,Cow,Dog,GuineaPig)
產(chǎn)品應用 Flow-Cyt=1μg/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 22 kDa
檢測分子量
細胞定位 細胞外基質(zhì) 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VEGFB: 101-207/207 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described and include fibroblast growth factor (FGF), platelet derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs). The VEGF protein family is comprised of VEGF, VEGF-B, VEGF-C and VEGF-D, all of which may exhibit angiogenic function in vivo. VEGF-B, which exists as two alternatively spliced isoforms known as VEGF-B167 and VEGF-B186, is abundantly expressed in heart and skeletal muscle and is frequently co-expressed with VEGF. VEGF-C binds to and specifically activates Flt-4 and Flk-1.

Function:
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

Subcellular Location:
Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

Tissue Specificity:
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.

Post-translational modifications:
VEGF-B167 is O-glycosylated.

Similarity:
Belongs to the PDGF/VEGF growth factor family.

SWISS:
P49765

Gene ID:
7423

Database links:

Entrez Gene: 7423 Human

Entrez Gene: 22340 Mouse

Entrez Gene: 89811 Rat

Omim: 601398 Human

SwissProt: P49765 Human

SwissProt: P49766 Mouse

SwissProt: O35485 Rat

Unigene: 78781 Human

Unigene: 15607 Mouse

Unigene: 198550 Rat



產(chǎn)品圖片
Blank control (blue line): A549 (fixed with 2% paraformaldehyde (10 min) , then permeabilized with 90% ice-cold methanol for 30 min on ice). Primary Antibody (green line): Rabbit Anti-VEGFB antibody (bs-10072R),Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-FITC,Dilution: 1μg /test.
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