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IL18 Rabbit pAb (bs-4988R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產(chǎn)品編號 bs-4988R
英文名稱 IL18 Rabbit pAb
中文名稱 白介素18抗體
別    名 Interleukin-18; interferon gamma-inducing factor IGIF; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; Iboctadekin; IFN gamma inducing factor; IGIF; IL 1 gamma; IL 18; IL-18; IL 1g; IL1 gamma; IL18 protein; IL1F4; IL1g; IL1gamma; ILIF4; Interferon gamma inducing factor; Interleukin 1 gamma; Interleukin18; MGC12320; IL18_HUMAN.  
Specific References  (2)     |     bs-4988R has been referenced in 2 publications.
[IF=4.486] Linzhao Li. et al. Mesenchymal stromal cells protect hepatocytes from lipotoxicity through alleviation of endoplasmic reticulum stress by restoring SERCA activity. 2021 Feb 16  WB ;  Human.  
[IF=2.311] Teng Ma. et al. Interleukin?18 and ?10 may be associated with lymph node metastasis in breast cancer. Oncol Lett. 2021 Apr;21(4):1-1  IHC ;  Human.  
研究領域 腫瘤  心血管  免疫學  細胞因子  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 22 kDa
檢測分子量
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-18/IGIF: 101-193/193 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 IL18 (IFN-gamma-inducing factor, IGIF) is a novel pro-inflammatory cytokine that augments natural killer (NK) activity in spleen cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.
IL18 also has other biological properties such as stimulation of Fas ligand expression, and induction of CC and CXC chemokines. IL18 increases production of competent HIV. IL18 is related to the IL1 family. One of the IL18 receptor chains is the IL1 receptor-related protein, a member of the IL 1R family. Like IL1 , IL18 is first synthesized as a leaderless precursor requiring the IL1 converting enzyme (ICE) for cleavage into an active molecule. IL18 may play a role in tissue injury in inflammatory reactions.

Function:
Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

Subcellular Location:
Secreted.

Similarity:
Belongs to the IL-1 family.

SWISS:
Q14116

Gene ID:
3606

Database links:

Entrez Gene: 3606 Human

Entrez Gene: 16173 Mouse

Omim: 600953 Human

SwissProt: Q14116 Human

SwissProt: P70380 Mouse

Unigene: 83077 Human

Unigene: 1410 Mouse




產(chǎn)品圖片
25 ug total protein per lane of various lysates (see on figure) probed with IL-18 polyclonal antibody, unconjugated (bs-4988R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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