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CLEC9A Rabbit pAb (bs-13621R)  
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產(chǎn)品編號(hào) bs-13621R
英文名稱 CLEC9A Rabbit pAb
中文名稱 C型凝集素結(jié)構(gòu)域家族9成員A抗體
別    名 C type lectin domain family 9, member A; C-type lectin domain family 9 member A; CLC9A_MOUSE; CLEC9A; DNGR1; HEEE9341; PRO34046; UNQ9341.  
Specific References  (1)     |     bs-13621R has been referenced in 1 publications.
[IF=8.701] Tatsuaki Watanabe. et al. Donor Batf3 inhibits murine lung allograft rejection and airway fibrosis. MUCOSAL IMMUNOL. 2023 Feb;:  IF ;  Mouse.  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞粘附分子  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Mouse (predicted: Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 27 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse CLEC9A: 1-100/238 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily consists of a variety of proteins that share a common protein fold and have diverse functions, including cell-cell signaling, cell adhesion, glycoprotein turnover and immune responses. CLEC-9A (C-type lectin domain family 9 member A), also known as DNGR1 (dendritic cell natural killer lectin group receptor 1), is a 241 amino acid single-pass type II membrane protein that contains one C-type lectin domain and belongs to the CTL/CTLD superfamily. Expressed in myeloid lineage cells, brain, spleen and thymus, CLEC-9A is a group V C-type lectin-like receptor (CTLR) that acts as an activation receptor. The gene encoding CLEC-9A maps to human chromosome 12p13.2 and mouse chromosome 6 F3.

Function:
Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.

Subcellular Location:
Membrane.

Tissue Specificity:
In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.

Post-translational modifications:
N-glycosylated.

Similarity:
Contains 1 C-type lectin domain.

SWISS:
Q8BRU4

Gene ID:
232414

Database links:

Entrez Gene: 232414 Mouse

SwissProt: Q8BRU4 Mouse

Unigene: 391518 Mouse



產(chǎn)品圖片
Sample: Spleen (Mouse) Lysate at 40 ug Primary: Anti- CLEC9A (bs-13621R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 27 kD Observed band size: 27 kD
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