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Claudin 19 Rabbit pAb (bs-13749R)  
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50ul/1180.00元
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產(chǎn)品編號 bs-13749R
英文名稱 Claudin 19 Rabbit pAb
中文名稱 緊密連接蛋白19抗體
別    名 Claudin 19; CLDN 19; CLD19_HUMAN.  
研究領域 細胞生物  信號轉導  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat,Sheep,Cow,Horse)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 23 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Claudin 19: 21-120/224 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and Junction adhesion molecules. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-19 is a 224 amino acid multi-pass membrane protein that belongs to the claudin family and is expressed as two isoforms due to alternative splicing events. Defects in the gene encoding claudin-19 are the cause of hypomagnesemia renal with ocular involvement (HOMGO), a renal disease characterized by hypomagnesemia, hypercalciuria and nephrocalcinosis.

Function:
CLDN19 belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the claudin family.

SWISS:
Q8N6F1

Gene ID:
149461

Database links:

Entrez Gene: 149461 Human

Omim: 610036 Human

SwissProt: Q8N6F1 Human



產(chǎn)品圖片
Tissue/cell: mouse stomach tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-claudin-19 Polyclonal Antibody, Unconjugated(bs-13749R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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