| 產(chǎn)品編號(hào) | bs-13754R |
| 英文名稱 | Rabbit Anti-Claudin 12 antibody |
| 中文名稱 | 緊密連接蛋白12抗體 |
| 別 名 | Claudin-12; Claudin12; CLD12_HUMAN; CLDN 12; CLDN12. |
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Specific References (4) | bs-13754R has been referenced in 4 publications.
[IF=3.775] Xue Y et al. Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague–Dawley rats. Food Chem Toxicol. 2019 Aug 4;133:110751. WB ; Rat.
[IF=3.36] Sadowska, Grazyna B., et al. "Ontogeny of Tight Junction Protein Expression in the Ovine Cerebral Cortex during Development." Neuroscience (2015). WB ; Sheep.
[IF=2.984] Ruirui Luoet al. Clostridium perfringens beta2 toxin induced in vitro oxidative damage and its toxic assessment in porcine small intestinal epithelial cell lines. Gene
. 2020 Oct 30;759:144999. IF ; pig.
[IF=2.984] WB, IF ; Pig.
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| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子 血管內(nèi)皮細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 24kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Claudin 12: 32-87/244 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The claudin superfamily consists of many structurally related proteins that are important structural and functional components of tight junctions. Claudin-12, also known as CLDN12, is a 244 amino acid multi-pass membrane protein that is expressed in the brain, duodenum, jejunum, ileum, and colon. Claudin-12 localizes to cell junctions and may be involved in tight junction integrity by regulating hyperammonemia. Ammonia can alter brain capillary endothelial cell gene expression and transporter function. Claudin-12 is upregulated in enterocytes through vitamin D receptors which strongly suggest that claudin-12 forms paracellular Ca(2+) channels in intestinal epithelia and may be critical for vitamin D-dependent calcium homeostasis. Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Subcellular Location: Cell junction > tight junction. Cell membrane. Similarity: Belongs to the claudin family. SWISS: P56749 Gene ID: 9069 Database links: Entrez Gene: 9069 Human Omim: 611232 Human SwissProt: P56749 Human Unigene: 258576 Human |
| 產(chǎn)品圖片 |
Sample:Liver (Mouse) Lysate at 40 ug
Primary: Anti-Claudin 12(bs-13754R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 24kD
Observed band size: 26kD
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