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Claudin 12 Rabbit pAb (bs-13754R)  
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產(chǎn)品編號 bs-13754R
英文名稱 Claudin 12 Rabbit pAb
中文名稱 緊密連接蛋白12抗體
別    名 Claudin-12; Claudin12; CLD12_HUMAN; CLDN 12; CLDN12.  
Specific References  (4)     |     bs-13754R has been referenced in 4 publications.
[IF=3.775] Xue Y et al. Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague–Dawley rats. Food Chem Toxicol. 2019 Aug 4;133:110751.  WB ;  Rat.  
[IF=3.36] Sadowska, Grazyna B., et al. "Ontogeny of Tight Junction Protein Expression in the Ovine Cerebral Cortex during Development." Neuroscience (2015).  WB ;  Sheep.  
[IF=2.984] Ruirui Luoet al. Clostridium perfringens beta2 toxin induced in vitro oxidative damage and its toxic assessment in porcine small intestinal epithelial cell lines. Gene . 2020 Oct 30;759:144999.  IF ;  pig.  
[IF=2.984]   WB, IF ;  Pig.  
研究領(lǐng)域 細胞生物  信號轉(zhuǎn)導(dǎo)  細胞粘附分子  血管內(nèi)皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Mouse (predicted: Human,Rat,Pig,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 24 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Claudin 12: 32-87/244 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The claudin superfamily consists of many structurally related proteins that are important structural and functional components of tight junctions. Claudin-12, also known as CLDN12, is a 244 amino acid multi-pass membrane protein that is expressed in the brain, duodenum, jejunum, ileum, and colon. Claudin-12 localizes to cell junctions and may be involved in tight junction integrity by regulating hyperammonemia. Ammonia can alter brain capillary endothelial cell gene expression and transporter function. Claudin-12 is upregulated in enterocytes through vitamin D receptors which strongly suggest that claudin-12 forms paracellular Ca(2+) channels in intestinal epithelia and may be critical for vitamin D-dependent calcium homeostasis.

Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Subcellular Location:
Cell junction > tight junction. Cell membrane.

Similarity:
Belongs to the claudin family.

SWISS:
P56749

Gene ID:
9069

Database links:

Entrez Gene: 9069 Human

Omim: 611232 Human

SwissProt: P56749 Human

Unigene: 258576 Human



產(chǎn)品圖片
Sample:Liver (Mouse) Lysate at 40 ug Primary: Anti-Claudin 12(bs-13754R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 24kD Observed band size: 26kD
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