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Scavenger Receptor BI + BII Rabbit pAb (bs-17277R)  
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50ul/1180.00元
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產(chǎn)品編號(hào) bs-17277R
英文名稱 Scavenger Receptor BI + BII Rabbit pAb
中文名稱 清道夫受體B1+B2抗體
別    名 85 kDa lysosomal membrane sialoglycoprotein; CD36 and LIMPII Analogous 1; CD36L1; CD36L2; CLA1; HLGP85; LGP85; LIMP II; Lysosome membrane protein II; MGC138242; SCARB1; SCARB2; Scavenger receptor class B member 2; Scavenger Receptor Class B Type I; SRBI; SRBII.  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞膜受體  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Human,Mouse (predicted: Rat,Rabbit,Pig,Sheep,Cow,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 61 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Scavenger Receptor BI + BII: 31-130/552 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Function:
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

Subcellular Location:
Lysosome; lysosomal membrane; multi-pass membrane protein.

SWISS:
Q8WTV0

Gene ID:
950

Database links:

Entrez Gene: 949 Human

Entrez Gene: 950 Human

Entrez Gene: 12492 Mouse

Entrez Gene: 20778 Mouse

Entrez Gene: 117106 Rat

Entrez Gene: 25073 Rat

Omim: 601040 Human

Omim: 602257 Human

SwissProt: Q14108 Human

SwissProt: Q8WTV0 Human

SwissProt: O35114 Mouse

SwissProt: Q61009 Mouse

SwissProt: P27615 Rat

SwissProt: P97943 Rat

Unigene: 298813 Human

Unigene: 349656 Human

Unigene: 592984 Human

Unigene: 282242 Mouse

Unigene: 297964 Mouse

Unigene: 399507 Mouse

Unigene: 410528 Mouse

Unigene: 3957 Rat

Unigene: 88169 Rat



產(chǎn)品圖片
Sample: Adrenal gland (Mouse) Lysate at 40 ug Primary: Anti- Scavenger Receptor BI + BII (bs-17277R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 61 kD Observed band size: 61 kD
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