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OGDH Rabbit pAb (bs-17710R)  
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產(chǎn)品編號 bs-17710R
英文名稱 OGDH Rabbit pAb
中文名稱 酮戊二酸脫氫酶OGDH抗體
別    名 2 oxoglutarate dehydrogenase; 2 oxoglutarate dehydrogenase complex component E1; 2 oxoglutarate dehydrogenase mitochondrial; 2-oxoglutarate dehydrogenase; 2-oxoglutarate dehydrogenase complex component E1; AKGDH; alpha ketoglutarate dehydrogenase; alpha-ketoglutarate dehydrogenase; E1k; mitochondrial; ODO1_HUMAN; OGDC; OGDC E1; OGDC-E1; OGDH; Oxoglutarate(alpha ketoglutarate) dehydrogenase(lipoamide); Oxoglutarate decarboxylase; Oxoglutarate dehydrogenase(lipoamide); Oxoglutarate dehydrogenase(succinyl transferring).  
Specific References  (1)     |     bs-17710R has been referenced in 1 publications.
[IF=3.333] Li X et al. lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma.Int J Oncol. 2018 Aug;53(2):551-566.  WB ;  Human.  
研究領域 細胞生物  免疫學  信號轉導  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Pig,Sheep,Cow,Horse)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 111 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human OGDH: 931-1023/1023 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

Function:
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Subcellular Location:
Mitochondrion matrix.

Similarity:
Belongs to the alpha-ketoglutarate dehydrogenase family.

SWISS:
Q02218

Gene ID:
4967

Database links:

Entrez Gene: 4967 Human

Entrez Gene: 18293 Mouse

Entrez Gene: 534599 Cow

Entrez Gene: 360975 Rat

Omim: 613022 Human

SwissProt: Q148N0 Cow

SwissProt: Q02218 Human

SwissProt: Q60597 Mouse

SwissProt: Q5XI78 Rat

Unigene: 488181 Human

Unigene: 276348 Mouse

Unigene: 472458 Mouse

Unigene: 45991 Rat



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (human breast); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (OGDH) Polyclonal Antibody, Unconjugated (bs-17710R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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