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SECISBP2 Rabbit pAb (bs-19622R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-19622R
英文名稱 SECISBP2 Rabbit pAb
中文名稱 硒蛋白SECIS結(jié)合蛋白2抗體
別    名 DKFZp686C09169; OTTHUMP00000064929; OTTHUMP00000064930; OTTHUMP00000064931; OTTHUMP00000064932; RP11 89K14.1; SBP 2; SBP2; SEBP2_HUMAN; SECIS binding protein 2; SECIS-binding protein 2; SECISBP 2; SECISBP2; Selenocysteine insertion sequence binding protein 2; Selenocysteine insertion sequence-binding protein 2.  
研究領域 細胞生物  發(fā)育生物學  信號轉(zhuǎn)導  干細胞  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 95 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SECISBP2: 471-570/854 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Function:
Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed at high levels in testis.

DISEASE:
Defects in SECISBP2 are a cause of abnormal thyroid hormone metabolism (ATHYHM) [MIM:609698]. This phenotype is associated with a reduction in type II iodothyronine deiodinase activity.

SWISS:
Q96T21

Gene ID:
79048

Database links:

Entrez Gene: 79048 Human

Entrez Gene: 464583 Chimpanzee

Entrez Gene: 511202 Cow

Entrez Gene: 476351 Dog

Entrez Gene: 101128509 Gorilla

Entrez Gene: 75420 Mouse

Entrez Gene: 79049 Rat

Entrez Gene: 697442 Rhesus monkey

Omim: 607693 Human

SwissProt: Q96T21 Human

SwissProt: Q9QX72 Rat

Unigene: 59804 Human

Unigene: 25076 Rat



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