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CYP3A1 Rabbit pAb (bs-20586R)  
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產(chǎn)品編號 bs-20586R
英文名稱 CYP3A1 Rabbit pAb
中文名稱 細胞色素CYP3A1抗體
別    名 Cytochrome P450 3A1; CYP3A; CYP3A1; cytochrome P450, family 3, subfamily a, polypeptide 1; glucocorticoid inducible P450; HLP; MGC126680; NF 25; NF25; Nifedipine oxidase; Niphedipine oxidase; P450 III steroid inducible; P450 PCN(PCNC inducible); P450 PCN1; P450C3; P450PCN1; Quinine 3 monooxygenase; Taurochenodeoxycholate 6 alpha hydroxylase; CP3A1_RAT.  
Specific References  (2)     |     bs-20586R has been referenced in 2 publications.
[IF=4.36] Xiangling Feng. et al. Inhibitory effects of traditional Chinese medicine colquhounia root tablet on the pharmacokinetics of tacrolimus in rats. J ETHNOPHARMACOL. 2022 Aug;294:115358  WB ;  Rat.  
[IF=1.785] Hongfang Li. et al. Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats. Exp Ther Med. 2021 Jun;21(6):1-9  WB ;  Rat.  
研究領(lǐng)域 腫瘤  心血管  細胞生物  信號轉(zhuǎn)導  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Rat
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 57 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat CYP3A1: 231-330/504 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 CYP3A proteins are P450 monooxygenases and in animals, P450 enzymes serve two major functions: biosynthesis of steroids, fatty acids and bile acids, and the metabolism of endogenous and exogenous substrates. A wide variety of exogenous substrates are metabolized by P450 enzymes, including toxins and drugs. The four major families involved in drug metabolism are CYP1, 2, 3 and 4. The hepatic CYP3A1 protein is detected throughout ciliated and nonciliated cells in seven-day-old rats, and is only detected in the apex of these cells in adult rats. Rat CYP3A1 and CYP3A2 share 89% homolgy, but differ by three out of five of their C-terminal residues.

Function:
In animals, P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. Cytochrome P450 3A4 [human-3A1 Rat] is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.

Subcellular Location:
Endoplasmic reticulum, membrane bound.

Post-translational modifications:
Polyubiquitinated in the presence of AMFR and UBE2G1 and alsoSTUB1/CHIP and UBE2D1 (in vitro).

Similarity:
Belongs to the cytochrome P450 family.

SWISS:
P04800

Gene ID:
25642

Database links:

Entrez Gene: 25642 Rat

SwissProt: P04800 Rat



產(chǎn)品圖片
Sample: Liver (Rat)Lysate at 40 ug Cerebrum (Rat)Lysate at 40 ug Primary: Anti-CYP3A1(bs-20586R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 57kD Observed band size: 57kD
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