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LDHB Rabbit pAb (bs-20294R)  
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50ul/1180.00元
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產(chǎn)品編號 bs-20294R
英文名稱 LDHB Rabbit pAb
中文名稱 乳酸脫氫酶抗體
別    名 Lactate Dehydrogenase B; Renal Carcinoma Antigen NY-REN-46; LDH Heart Subunit; EC 1.1.1.27; LDH-B; LDH-H; Epididymis Secretory Protein Li 281; Lactate Dehydrogenase H Chain; HEL-S-281; EC 1.1.1; LDHBD; TRG-5; LDHB_HUMAN;  
Specific References  (1)     |     bs-20294R has been referenced in 1 publications.
[IF=4.486] Du Y et al. ATPR triggers acute myeloid leukaemia cells differentiation and cycle arrest via the RARα/LDHB/ERK‐glycolysis signalling axis. J Cell Mol Med. 2020 Jun; 24(12): 6952–6965.  IHC ;  mouse.  
研究領(lǐng)域 細胞生物  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Pig,Cow)
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 37 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LDHB: 181-250/334 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Recent studies have shown that two protein isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism, and that these C-terminally distinct isoforms have different subcellular localization. Alternatively spliced transcript variants have also been found for this gene. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Oct 2015]

Function:
This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Subunit:
Homotetramer.

Subcellular Location:
Cytoplasm

Similarity:
Belongs to the LDH/MDH superfamily. LDH family.

SWISS:
P07195

Gene ID:
3945

Database links:

Entrez Gene: 3945 Human

Entrez Gene: 16832 Mouse

Entrez Gene: 24534 Rat

Omim: 150100 Human

SwissProt: P07195 Human

SwissProt: P16125 Mouse

SwissProt: P42123 Rat

Unigene: 446149 Human

Unigene: 9745 Mouse

Unigene: 1785 Rat



產(chǎn)品圖片
Sample: Heart (Mouse) Lysate at 40 ug Kidney (Mouse) Lysate at 40 ug Jurkat (Human) Lysate at 40 ug Primary: Anti-LDHB (bs-20294R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 37 kD Observed band size: 37 kD
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