| 產(chǎn)品編號 | bsm-33063M |
| 英文名稱 | CDX2 Mouse mAb |
| 中文名稱 | 尾型同源盒轉(zhuǎn)錄因子2單克隆抗體 |
| 別 名 | cau-dal-related homeobox transcription factor 2; Caudal type homeo box 2; Caudal type homeobox protein 2; caudal type homeobox transcription factor 2; CDX 2; CDX 3; CDX3; Homeobox protein CDX-2; Homeobox protein CDX2; CDX2_HUMAN. |
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Specific References (1) | bsm-33063M has been referenced in 1 publications.
[IF=4.175] Li Liang. et al. Identification of key genes involved in tumor immune cell infiltration and cetuximab resistance in colorectal cancer. Cancer Cell Int. 2021 Dec;21(1):1-22 IHC ;
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| 研究領(lǐng)域 | 腫瘤 發(fā)育生物學(xué) 染色質(zhì)和核信號 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號 | 5G8 |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 34 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDX2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. This gene is a member of the caudal-related homeobox transcription factor family that is expressed in the nuclei of intestinal epithelial cells. CDX2 is also used in diagnostic surgical pathology as a marker for gastrointestinal differentiation, especially colorectal. Function: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylation of Ser-60 mediates the transactivation capacity. Similarity: Belongs to the Caudal homeobox family. Contains 1 homeobox DNA-binding domain. SWISS: Q99626 Gene ID: 1045 Database links: Entrez Gene: 1045 Human Entrez Gene: 12591 Mouse Omim: 600297 Human SwissProt: Q99626 Human SwissProt: P43241 Mouse Unigene: 174249 Human Unigene: 20358 Mouse Unigene: 64495 Rat 核轉(zhuǎn)錄因子抗體 CDX2表達(dá)主要用于消化系統(tǒng)腫瘤及癌前病變的研究。用于與腫瘤的增值、分化、大小、臨床分期及分化程度等關(guān)系方面的研究。CDX2是一種腸特異的轉(zhuǎn)錄因子，CDX2能夠調(diào)節(jié)腸上皮細(xì)胞的增殖和分化，定位于腸上皮的絨毛和隱窩表面。據(jù)報道95%以上的浸潤性結(jié)/直腸癌中均可檢出CDX2陽性表達(dá)，也可在胃癌和卵巢黏液性腺癌中表達(dá)。 |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (Rat colon); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CDX2) Monoclonal Antibody, Unconjugated (ascites of bsm-33063M 5G8) at 1:2000 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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