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CD27 Rabbit pAb (bs-23615R)  
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產(chǎn)品編號 bs-23615R
英文名稱 CD27 Rabbit pAb
中文名稱 CD27抗體
別    名 CD 27; CD27 antigen; CD27 molecule; CD27_HUMAN; CD27L receptor; LPFS2; MGC20393; OTTHUMP00000238557; S152; T cell activation antigen CD27; T cell antivation antigen S152; T-cell activation antigen CD27; T14; TNFRSF 7; TNFRSF7; TNFSF7; Tp 55; Tp55; Tumor necrosis factor receptor superfamily member 7.  
研究領域 腫瘤  免疫學  干細胞  淋巴細胞  t-淋巴細胞  細胞因子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse)
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 27 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD27: 101-200/250 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

Function:
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Subunit:
Homodimer. Interacts with SIVA1 and TRAF2.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Found in most T-lymphocytes.

Post-translational modifications:
Phosphorylated.
O-glycosylated with core 1 or possibly core 8 glycans.

Similarity:
Contains 3 TNFR-Cys repeats.

SWISS:
P26842

Gene ID:
939

Database links:

Entrez Gene: 939 Human

Entrez Gene: 21940 Mouse

Entrez Gene: 500318 Rat

Omim: 186711 Human

SwissProt: P26842 Human

SwissProt: P41272 Mouse

Unigene: 355307 Human

Unigene: 367714 Mouse

Unigene: 134200 Rat



產(chǎn)品圖片
Sample: Lane 1: Molt-4 (Human) Cell Lysate at 30 ug Lane 2: Jurkat (Human) Cell Lysate at 30 ug Primary: Anti-CD27 (bs-23615R) at 1/1000 dilution Anti-beta-Actin (bs-0061R) at 1/2000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50-55 kD Observed band size: 60 kD
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