| 產(chǎn)品編號(hào) | bs-24241R |
| 英文名稱 | Rabbit Anti-MRP1/ABCC1 antibody |
| 中文名稱 | 多藥耐藥相關(guān)蛋白1抗體 |
| 別 名 | Multidrug Resistanec-Associated Protein 1; ABC 29; ABC29; ABCC 1; ABCC; ABCC1; ATP binding cassette sub family C (CFTR/MRP) member 1; ATP binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C(4) transporter; LTC4 transporter; MRP 1; MRP; Multidrug resistance associated protein 1; Multidrug resistance protein; Multiple drug resistance associated protein; Multiple drug resistance protein 1; MRP1_HUMAN. |
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Specific References (3) | bs-24241R has been referenced in 3 publications.
[IF=5.923] Susumu Ohya. et al. KCa1.1 K+ Channel Inhibition Overcomes Resistance to Antiandrogens and Doxorubicin in a Human Prostate Cancer LNCaP Spheroid Model. Int J Mol Sci. 2021 Jan;22(24):13553 WB ; Human.
[IF=4.546] Huang, Wenjie. et al. The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters. CHIN MED-UK. 2022 Dec;17(1):1-18 WB ; Human.
[IF=2.389] Huang Weizhen. et al. LncRNA SNHG11 enhances bevacizumab resistance in colorectal cancer by mediating miR-1207-5p/ABCC1 axis. ANTI-CANCER DRUG. 2022 Jul;33(6):575-586 WB ; Human.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Sheep,Cow,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 170kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MRP1/ABCC1: 1131-1230/1531 <Cytoplasmic> |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012] Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Lung, testis and peripheral blood mononuclear cells. Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. SWISS: P33527 Gene ID: 4363 Database links: Entrez Gene: 4363 Human Entrez Gene: 17250 Mouse Omim: 158343 Human SwissProt: P33527 Human SwissProt: O35379 Mouse Unigene: 391464 Human Unigene: 196634 Mouse Unigene: 10495 Rat 多藥耐藥相關(guān)蛋白1(MRP1)是MRP家族中的一個(gè)成員之一，基因的染色體位點(diǎn)是16p13.1，它編碼分子量是170-190kDa的MRP1蛋白。 MRP1又稱ABCC1主要表達(dá)在消化系統(tǒng)中的肝臟、結(jié)腸和胰腺組織中，常用于多種腫瘤的多藥耐藥機(jī)制的研究。 |
| 產(chǎn)品圖片 |
Bone (Mouse) Lysate at 40 ug Primary: Anti-MRP1/ABCC1 (bs-24241R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 170 kD Observed band size: 170 kD
Sample:
Testis (Mouse) Lysate at 40 ug
Primary: Anti-MRP1/ABCC1 (bs-24241R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 170 kD
Observed band size: 170 kD
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