| 產(chǎn)品編號(hào) | bsm-51726M |
| 英文名稱 | FAT4 Mouse mAb |
| 中文名稱 | FAT4單克隆抗體 |
| 別 名 | CDHF14; FAT4_HUMAN; Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; FATJ; hFat4; Nbla00548; Protocadherin Fat 4. |
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Specific References (1) | bsm-51726M has been referenced in 1 publications.
[IF=3.738] Yang, Yuying. et al. FAT4 activation inhibits epithelial-mesenchymal transition (EMT) by promoting autophagy in H2228/Cer cells. MED ONCOL. 2023 Jan;40(1):1-12 WB ; Human.
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| 研究領(lǐng)域 | 腫瘤 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子 細(xì)胞分化 |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號(hào) | H10M4 |
| 交叉反應(yīng) | Human,Recombinant protein |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 538 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human FAT4 between 4500-4786 amino acids |
| 亞 型 | IgG1, k |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014] Function: May function in the regulation of planar cell polarity. Cadherins are cell-cell interaction molecules. Subcellular Location: Membrane. In the kidney, localizes to primary cilia. Tissue Specificity: Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer. Similarity: Contains 34 cadherin domains. Contains 6 EGF-like domains. Contains 2 laminin G-like domains. SWISS: Q6V0I7 Gene ID: 79633 Database links: Entrez Gene: 79633 Human SwissProt: Q6V0I7 Human Unigene: 563205 Human |
| 產(chǎn)品圖片 |
Sample:
Lane 1: FAT4 Recombinant protein
Primary: Anti-FAT4 (bsm-51726M) at 1/2000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 538 kD
Observed band size: 45 kD
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