| 產(chǎn)品編號(hào) | bsm-63137R |
| 英文名稱(chēng) | phospho-FAK (Y397) Recombinant Rabbit mAb |
| 中文名稱(chēng) | 磷酸化粘著斑激酶重組兔單抗 |
| 別 名 | EC 2.7.10.2; FADK 1; FAK1; Focal adhesion kinase 1; PTK2; Protein- tyrosine kinase 2; pp125FAK. |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Recombinant |
| 克 隆 號(hào) | 4B2 |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ICC/IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 119 kDa |
| 檢測(cè)分子量 | 119 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Focal adhesion kinase 1 around the phosphorylation site of Y397: DD-pY-AE |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. SWISS: Q05397 Gene ID: 5747 FAK是整合蛋白介導(dǎo)的信號(hào)轉(zhuǎn)導(dǎo)中的重要成員,有酪氨酸蛋白激酶活性,并可自身磷酸化,FAK本身是胱冬肽酶(caspase)的底物。作為信號(hào)分子的FAK參與抑制細(xì)胞凋亡并直接參與細(xì)胞多種功能的調(diào)節(jié)。 1.FAK 局部粘著斑激酶，是一種酪氨酸激酶;腫瘤細(xì)胞的侵襲性生長(zhǎng)是一個(gè)多步驟的復(fù)雜過(guò)程，有多種生物化學(xué)因子參與其中,局部粘著斑激酶（focal adhesion kinase, FAK）介導(dǎo)的信號(hào)轉(zhuǎn)導(dǎo)系統(tǒng)就是其中最為重要的細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)途徑之一。腫瘤細(xì)胞必須黏附于細(xì) |
