| 產(chǎn)品編號 | bsm-63180R |
| 英文名稱 | phospho-STAT1 (Y701) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化信號轉(zhuǎn)導(dǎo)與轉(zhuǎn)錄激活因子1重組兔單抗 |
| 別 名 | CANDF7; ISGF 3; Signal transducer and activator of transcription 1; Stat1; STAT91; Transcription factor ISGF-3 components p91/p84. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | 4F11 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 87 kDa |
| 檢測分子量 | 87 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human STAT1 around the phosphorylation site of Y701: TG-pY-IK |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. SWISS: P42224 Gene ID: 6772 轉(zhuǎn)錄調(diào)節(jié)因子（Transcriptin Regulators） 信號轉(zhuǎn)導(dǎo)與轉(zhuǎn)錄激活因子1(STAT1)是一種重要的核轉(zhuǎn)錄因子,主要位于細(xì)胞漿,當(dāng)細(xì)胞受到外界信號刺激時,STAT1發(fā)生磷酸化而被激活并轉(zhuǎn)入細(xì)胞核參與靶基因的轉(zhuǎn)錄調(diào)控，參與細(xì)胞的信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄。 |
