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Human AIF Ready-To-Use IHC Kit (IHC0318H)  
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產(chǎn)品編號 IHC0318H
英文名稱 Human AIF Ready-To-Use IHC Kit
中文名稱 人凋亡誘導因子即用型免疫組化試劑盒
別    名 AIF, AIFM1, AIFsh2, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, Hq, NADMR, NAMSD, PDCD8  
適用樣品基質(zhì) FFPE tissue
保存條件 Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.
產(chǎn)品介紹 Apoptosis Inducing Factor (AIF) causes chromatin condensation and DNA fragmentation. AIF was recently identified, and cloned. Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli. AIF is highly conserved between human and mouse and widely expressed. Mutations in the AIF gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants of AIF and a related pseudogene has been identified on chromosome 10.

SWISS:
O95831

Gene ID:
9131

產(chǎn)品圖片
Immunohistochemical analysis of paraffin embedded human kidney tissue slide using IHC0318H (Human AIF Kit).
Immunohistochemical analysis of paraffin embedded human colon cancer tissue slide using IHC0318H (Human AIF Kit).
Immunohistochemical analysis of paraffin embedded human testis tissue slide using IHC0318H (Human AIF Kit).
Immunohistochemical analysis of paraffin embedded human hepatocellular carcinoma tissue slide using IHC0318H (Human AIF Kit).
Immunohistochemical analysis of paraffin embedded human liver tissue slide using IHC0318H (Human AIF Kit).
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