| 產(chǎn)品編號 | IHC0340H |
| 英文名稱 | Human Shh Ready-To-Use IHC Kit |
| 中文名稱 | 人Shh信號轉(zhuǎn)導通路膜蛋白受體即用型免疫組化試劑盒 |
| 別 名 | 9530036O11Rik, Dsh, HHG1, HLP3, HPE3, Hx, Hxl3, M100081, MCOPCB5, SHH, SMMCI, TPT, TPTPS, Vhh-1 |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Sonic Hedgehog (SHH), which is expressed only during embryogenesis, is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the Sonic Hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. In addition, it is thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. SWISS: Q15465 Gene ID: 6469 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human pancreatic cancer tissue slide using IHC0340H (Human Shh Kit).
Immunohistochemical analysis of paraffin embedded human kidney tissue slide using IHC0340H (Human Shh Kit).
Immunohistochemical analysis of paraffin embedded human hepatocellular carcinoma tissue slide using IHC0340H (Human Shh Kit).
Immunohistochemical analysis of paraffin embedded human liver tissue slide using IHC0340H (Human Shh Kit).
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| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關(guān)于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
