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CD147 Recombinant Rabbit mAb (bsm-52837R)  
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50ul/1400.00元
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產(chǎn)品編號 bsm-52837R
英文名稱 CD147 Recombinant Rabbit mAb
中文名稱 CD147重組兔單抗
別    名 TCSF; Emmprin; 5A11 antigen; 5F7; Basigin(Ok blood group); Basigin; Blood brain barrier HT7 antigen; BSG; CD 147; CD147 antigen; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; Leukocyte activation antigen M6; M6; M6 leukocyte activation antigen; neurothelin; OK; OK blood group; OK blood group antigen; TCSF; Tumor cell derived collagenase stimulatory factor; BASI_HUMAN.  細胞外基質(zhì)金屬蛋白酶誘導(dǎo)因子抗體
Specific References  (1)     |     bsm-52837R has been referenced in 1 publications.
[IF=2.934] Xuejiao Zhu. et al. Basigin-CyP elevated porcine circovirus type2 replication. Virus Res. 2020 Nov;289:198152  
研究領(lǐng)域 腫瘤  免疫學  合成與降解  細胞表面分子  
抗體來源 Rabbit
克隆類型 Recombinant
克 隆 號 12C3
交叉反應(yīng) Human,Mouse,Rat
產(chǎn)品應(yīng)用 WB=1:1000-2000,IHC-P=1:100-500,IHC-F=1:50-200,IF=1:50-200,ICC/IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 42 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human CD147 protein 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antib
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.

Subunit:
Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Melanosome.

Tissue Specificity:
Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Post-translational modifications:
N-glycosylated.

Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

SWISS:
P35613

Gene ID:
682

Database links:

Entrez Gene: 682 Human

Entrez Gene: 12215 Mouse

Entrez Gene: 25246 Rat

Omim: 109480 Human

SwissProt: P35613 Human

SwissProt: P18572 Mouse

SwissProt: P26453 Rat

Unigene: 501293 Human



產(chǎn)品圖片
Sample: Lane 1: Cerebrum (Mouse) Lysate at 40 ug Lane 2: Liver (Mouse) Lysate at 40 ug Lane 3: Eye (Mouse) Lysate at 40 ug Lane 4: Cerebrum (Rat) Lysate at 40 ug Lane 5: Liver (Rat) Lysate at 40 ug Lane 6: HepG2 (Human) Cell Lysate at 30 ug Lane 7: MCF-7 (Human) Cell Lysate at 30 ug Primary: Anti-CD147 (bsm-52837R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40-70 kD Observed band size: 58 kD
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