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Rabbit Anti-NARC1/PCSK9/HRP Conjugated antibody (bs-6060R-HRP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6060R-HRP
英文名稱 Rabbit Anti-NARC1/PCSK9/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標(biāo)記的神經(jīng)細(xì)胞凋亡調(diào)節(jié)轉(zhuǎn)化蛋白1/前蛋白轉(zhuǎn)化酶枯草溶菌素9抗體
別    名 FH3; HCHOLA3; Hypercholesterolemia autosomal dominant 3; NARC 1; NARC-1; NARC1; Neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; PC 9; PC9; PCSK 9; PCSK9; PCSK9_HUMAN; Proprotein convertase 9; Proprotein convertase PC9; Proprotein convertase subtilisin/kexin type 9; PSEC0052; Subtilisin/kexin like protease PC9; Subtilisin/kexin-like protease PC9.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 心血管  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, )
產(chǎn)品應(yīng)用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PCSK9/NARC1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.

Function:
The precursor protein but not the mature protein may form multimers.

Subunit:
The precursor protein but not the mature protein may form multimers.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

Post-translational modifications:
The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.

Similarity:
Belongs to the peptidase S8 family.
Contains 1 peptidase S8 domain.

Database links:

Entrez Gene: 255738 Human

Entrez Gene: 100102 Mouse

Entrez Gene: 298296 Rat

Omim: 607786 Human

SwissProt: Q8NBP7 Human

SwissProt: Q80W65 Mouse

SwissProt: P59996 Rat

Unigene: 18844 Human

Unigene: 133268 Mouse

Unigene: 19195 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

前蛋白轉(zhuǎn)化酶枯草溶菌素9(PCSK9)是近年來新發(fā)現(xiàn)的一種與調(diào)節(jié)脂質(zhì)代謝密切相關(guān)的基因,編碼前蛋白轉(zhuǎn)化酶NARC-1。Narc-1/pcsk9可通過調(diào)節(jié)細(xì)胞表面的低密度脂蛋白受體(LDLR)水平,參與脂質(zhì)代謝,從而在動(dòng)脈粥樣硬化性疾病的發(fā)生、發(fā)展中發(fā)揮重要作用。
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