| 產(chǎn)品編號 | bs-2947R-PE |
| 英文名稱 | Rabbit Anti-C-4 Methylsterol Oxidase/PE Conjugated antibody |
| 中文名稱 | PE標(biāo)記的甲基固醇羥化酶單加氧酶1抗體 |
| 別 名 | 1500001G16Rik; C 4 methyl sterol; C78600; DESP4; ERG25; Methylsterol monooxygenase 1; MGC104344; MSMO1; MSMO1_HUMAN; OTTHUMP00000219757; OTTHUMP00000219758; OTTHUMP00000219759; OTTHUMP00000219760; sterol C4 methyl oxidase like. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ERG25 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Belonging to the sterol desaturase family, ERG25 is a 293 amino acid enzyme that performs the first of three enzymatic steps required to remove the two methyl groups leading to cholesterol. ERG25 is a multi-pass membrane protein that resides within the plasma membrane and the membrane of the endoplasmic reticulum. Concentrations of ERG25 mRNA increase when subjected to low iron growth conditions, suggesting that the enzyme is not regulated by iron but by an end product of the ergosterol pathway. Low-density lipoprotein (LDL) downregulates ERG25 expression in the vascular wall, an event that may be inhibited via SREBP overexpression. ERG25 is encoded by a gene located on human chromosome 4q32.3. Function: Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. DISEASE: Microcephaly, congenital cataract, and psoriasiform dermatitis (MCCPD) [MIM:616834]: An autosomal recessive inborn error of cholesterol metabolism characterized by accumulation of a large amount of methylsterols, particularly dimethylsterols, in affected individuals. Patients manifest psoriasiform dermatitis, arthralgias, congenital cataracts, microcephaly, and developmental delay. {ECO:0000269|PubMed:21285510, ECO:0000269|PubMed:24144731}. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the sterol desaturase family. Database links: Entrez Gene: 6307 Human Entrez Gene: 66234 Mouse Omim: 607545 Human SwissProt: Q15800 Human SwissProt: Q9CRA4 Mouse Unigene: 105269 Human Unigene: 30119 Mouse Unigene: 7167 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
