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Rabbit Anti-ATF3/Gold Conjugated antibody (bs-0519R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0519R-Gold
英文名稱 Rabbit Anti-ATF3/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的活化轉(zhuǎn)錄因子3抗體
別    名 Activating transcription factor 3; ATF3deltaZip2; ATF3deltaZip2c; ATF3deltaZip3; cAMP dependent transcription factor ATF3; Cyclic AMP dependent transcription factor ATF3; Cyclic AMP-dependent transcription factor ATF-3; TF3_HUMAN; cAMP-dependent transcription factor ATF-3; cyclic AMP-dependent transcription factor ATF-3 isoform 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Chicken, Dog, Cow, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 20kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ATF3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011].

Function:
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

Subunit:
Binds DNA as a homodimer or a heterodimer.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the bZIP family. ATF subfamily.
Contains 1 bZIP domain.

Database links:

Entrez Gene: 467 Human

Entrez Gene: 11910 Mouse

Entrez Gene: 25389 Rat

Omim: 603148 Human

SwissProt: P18847 Human

SwissProt: Q60765 Mouse

SwissProt: P29596 Rat

Unigene: 460 Human

Unigene: 2706 Mouse

Unigene: 9664 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

轉(zhuǎn)錄調(diào)節(jié)因子(Transcriptin Regulators)

活化轉(zhuǎn)錄因子-3(屬于activation transcription factor/cAMP responsive element binding protein家族)是真核細(xì)胞轉(zhuǎn)錄因子,同屬于ATF/CREB家族。參與由cAMP或某些病毒蛋白質(zhì)所誘導(dǎo)基因轉(zhuǎn)錄的調(diào)節(jié)。
轉(zhuǎn)錄激活因子3(activating transcription factor 3,ATF3)屬含亮氨酸拉鏈結(jié)構(gòu)的轉(zhuǎn)錄因子ATF/CREB家族成員,分子量20kDa,在大部分正常細(xì)胞中呈低濃度穩(wěn)態(tài)表達(dá)。在正常組織中含量很低,在應(yīng)激狀態(tài)是表達(dá)增加,形成二聚體。ATF3是個應(yīng)激早期快反應(yīng)基因,體內(nèi)外可被一系列損傷性應(yīng)激信號快速誘導(dǎo)表達(dá)。ATF3不僅在應(yīng)激反應(yīng)中是個關(guān)鍵性的調(diào)控因子,還廣泛參與了機(jī)體穩(wěn)態(tài)維持、創(chuàng)傷愈合、細(xì)胞黏附、腫瘤形成、凋亡以及信號傳導(dǎo)等生理和病理過程。ATF3與細(xì)胞生存和凋亡有關(guān),但在不同的細(xì)胞狀態(tài)下發(fā)揮不同甚至相反的作用。
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