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Rabbit Anti-CK7/Gold Conjugated antibody (bs-1610R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1610R-Gold
英文名稱 Rabbit Anti-CK7/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的細(xì)胞角蛋白7抗體
別    名 Cytokeratin 7; CK 7; K7; Keratin 7; Keratin,type II cytoskeletal 7; KRT7; SCL; K2C7_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  信號轉(zhuǎn)導(dǎo)  細(xì)胞類型標(biāo)志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from the middle of human CK7
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 – 7.8. The individual human cytokeratins are designated 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

Function:
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).

Subunit:
Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.

Post-translational modifications:
Arg-20 is dimethylated, probably to asymmetric dimethylarginine.

Similarity:
Belongs to the intermediate filament family.

Database links:

Entrez Gene: 3855 Human

Omim: 148059 Human

SwissProt: P08729 Human

Unigene: 411501 Human

Unigene: 670221 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

結(jié)構(gòu)蛋白(Structural Proteins)
CK-7是一種 54KDa 的中間絲蛋白,存在于大多數(shù)正常組織的腺上皮和移行上皮細(xì)胞中。 該抗體與多種良/惡性上皮性腫瘤反應(yīng)。腺癌中的卵巢、乳腺、肺的腺癌呈陽性反應(yīng),而胃腸道的腺癌陰性。移行細(xì)胞腫瘤、前列腺癌也呈陽性反應(yīng)。通常認(rèn)為 CK7是腺癌和移行上皮細(xì)胞癌的比較特異性的標(biāo)志。
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