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Rabbit Anti-Sprouty 2/Gold Conjugated antibody (bs-7507R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-7507R-Gold
英文名稱 Rabbit Anti-Sprouty 2/Gold Conjugated antibody
中文名稱 膠體金標記的快速發(fā)育生長因子同源蛋白2抗體
別    名 hSPRY 2; hSPRY2; MGC23039; Sprouty homolog 2 (Drosophila); Sprouty homolog 2; Sprouty2; Spry 2; Spry2; SPY2_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  心血管  細胞生物  神經生物學  干細胞  生長因子和激素  血管內皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Sprouty 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Sprouty was originally identified as an inhibitor of Drosophila epidermal growth factor (EGF) and fibroblast growth factor (FGF) receptor signaling during tracheal development. Four isoforms of mammalian sprouty are known (Spry1-Spry4). The role of the mammalian analogs has not been clearly elucidated although it is believed that human Sprouty 2 (hSpry2) may be an inhibitor of cellular migration and proliferation. Spry2 and Spry4 show considerable sequence homology between human and mouse at the C terminus of the protein. Significant sequence divergence occurs at the N terminus. Spry2 appears to be abundant in brain, lung and heart tissue, with lesser amounts found in kidney and skeletal muscle.

Function:
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Subunit:
Interacts with RAF1.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor).

Similarity:
Belongs to the sprouty family.
Contains 1 SPR (sprouty) domain.

Database links:

Entrez Gene: 10253 Human

Entrez Gene: 24064 Mouse

Entrez Gene: 306141 Rat

Omim: 602466 Human

SwissProt: O43597 Human

SwissProt: Q9QXV8 Mouse

Unigene: 18676 Human

Unigene: 89982 Mouse

Unigene: 103294 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Sprouty2是一類在全身組織廣泛表達的軟脂?;椎鞍?在機體的信號轉導,尤其是受體蛋白對受體酪氨酸激酶(RTK)等信號通路起著重要的抑制作用,其表達在多種腫瘤組織中發(fā)生明顯下降,并可進一步引起細胞異常增殖、轉化及新生血管形成,從而促進腫瘤的發(fā)生及發(fā)展。
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