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Rabbit Anti-KY/BF350 Conjugated antibody (bs-11174R-BF350)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11174R-BF350
英文名稱 Rabbit Anti-KY/BF350 Conjugated antibody
中文名稱 BF350標記的脊柱側后凸畸形肽酶抗體
別    名 KY; KY_HUMAN; Kyphoscoliosis peptidase.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 發(fā)育生物學  神經生物學  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 75kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Kyphoscoliosis peptidase
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
KY peptidase (Kyphoscoliosis peptidase) is a 561 amino acid cytoskeleton protease that interacts with several sarcomeric cytoskeletal proteins, including Filamin 2. KY peptidase probably plays a role in the maturation, function and stabilization of the neuromuscular junction. KY-null mouse mutants exhibit distinct irregular subceullular Filamin 2 localization, suggesting that KY peptidase deficiency may be the cause of several types of limb-girdle muscular dystrophies.

Function:
Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC.

Subunit:
Interacts with IGFN1 and FLNC.

Subcellular Location:
Cytoplasm

Tissue Specificity:
Specifically expressed in skeletal and cardiac muscle.

Similarity:
Belongs to the transglutaminase-like superfamily.

Database links:

Entrez Gene: 339855 Human

Entrez Gene: 16716 Mouse

Omim: 605739 Human

SwissProt: Q8NBH2 Human

SwissProt: Q8C8H8 Mouse

Unigene: 146730 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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