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Rabbit Anti-PCYT1A /Gold Conjugated antibody (bs-11306R-Gold)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-11306R-Gold
英文名稱 Rabbit Anti-PCYT1A /Gold Conjugated antibody
中文名稱 膠體金標記的磷酸乙醇胺轉(zhuǎn)移酶A抗體
別    名 CCT A; CCT alpha; CCT-alpha; Choline phosphate cytidylyltransferase A; Choline-phosphate cytidylyltransferase A; CT A; CT antibody CTP:phosphocholine cytidylyltransferase A; CTPCT; PCY1A_HUMAN; PCYT1; Pcyt1a; Phosphate cytidylyltransferase 1 choline alpha; Phosphate cytidylyltransferase 1 choline alpha isoform; Phosphorylcholine transferase A.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  生長因子和激素  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PCYT1A
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Increase in fetal surfactant synthesis and lung maturity is caused by the glucocorticoidal induction of enzymes required for phosphatidylcholine synthesis towards the end of gestation (1). The regulation of gestational age-dependent induction of phosphatidylcholine synthesis by glucocorticoids is still unclear (1). The rate-controlling enzyme in the phosphatidylcholine biosynthetic pathway is CTP-phosphocholine cytidylyltransferase A (CCT A) (2–4). In cultured eukaryotic cells, this enzyme is essential for survival (3). The alpha isoform is located in the nucleus and is regulated by reversible phosphorylation and membrane association (3). There is significant identity between the alpha-helical membrane-binding domains of CCT A and soybean oleosin (2). Expressed CCT A has lipid-dependent cytidylyltransferase activity (5). The gene which encodes CCT A maps to human chromosome 3q (4).

Function:
Controls phosphatidylcholine synthesis.

Subunit:
Homodimer.

Subcellular Location:
Cytoplasm; cytosol. Membrane. It can interconvert between an inactive cytosolic form and an active membrane-bound form.

Post-translational modifications:
The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation.

Similarity:
Belongs to the cytidylyltransferase family.

Database links:

Entrez Gene: 5130 Human

Entrez Gene: 13026 Mouse

Omim: 123695 Human

SwissProt: P49585 Human

SwissProt: P49586 Mouse

Unigene: 135997 Human

Unigene: 98775 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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