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Rabbit Anti-UBR4/BF594 Conjugated antibody (bs-17092R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-17092R-BF594
英文名稱 Rabbit Anti-UBR4/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的E3泛素蛋白連接酶UBR4抗體
別    名 Ubiquitin Protein Ligase E3 Component N-Recognin 4; Retinoblastoma-Associated Factor Of 600 KDa; Zinc Finger UBR1-Type Protein 1; N-Recognin-4; RBAF600; ZUBR1; P600; Retinoblastoma-Associated Factor 600-Like Protein; 600 KDa Retinoblastoma Protein-Associated Factor; E3 Ubiquitin-Protein Ligase UBR4; Zinc Finger, UBR1 Type 1; EC 6.3.2.-; KIAA0462 KIAA1307; EC 6.3.2; GC01M019074; UBR4_HUMAN;   
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞骨架  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 574kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human UBR4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

Subunit:
Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11.

Subcellular Location:
Membrane Curated; Multi-pass membrane protein; Cytoplasm; cytoskeleton; Nucleus

Similarity:
Belongs to the UBR4 family.

Database links:

HGNC: 30313

Entrez Gene: 23352

Ensembl: ENSG00000127481

OMIM: 609890

UniProtKB: Q5T4S7



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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