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Rabbit Anti-SPHK1/BF594 Conjugated antibody (bs-2652R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2652R-BF594
英文名稱 Rabbit Anti-SPHK1/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的鞘氨醇激酶1抗體
別    名 sphingosine kinase 1; SK 1; SK1; SPHK 1; SPHK; SPK; SPK 1; SPK1; Sphk1; SPHK1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  激酶和磷酸酶  細(xì)胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Dog, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42-52kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPHK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Function:
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.

Tissue Specificity:
Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle.

Similarity:
Contains 1 DAGKc domain.

Database links:

Entrez Gene: 8877 Human

Entrez Gene: 20698 Mouse

Entrez Gene: 170897 Rat

Omim: 603730 Human

SwissProt: Q9NYA1 Human

SwissProt: Q8CI15 Mouse

SwissProt: Q91V26 Rat

Unigene: 68061 Human

Unigene: 20944 Mouse

Unigene: 18522 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SPHK1參與鞘氨醇代謝、G蛋白偶聯(lián)受體蛋白信號轉(zhuǎn)導(dǎo)途徑,有抗細(xì)胞凋亡的作用,可被蛋白激酶C激活,參與細(xì)胞內(nèi)信號轉(zhuǎn)導(dǎo)級聯(lián)、鈣介導(dǎo)信號轉(zhuǎn)導(dǎo)、調(diào)控細(xì)胞生長遷移、調(diào)控血管生成及成纖維細(xì)胞增殖。
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