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Rabbit Anti-GDF15/BF555 Conjugated antibody (bs-3818R-BF555)
訂購(gòu)熱線:400-901-9800
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3818R-BF555
英文名稱 Rabbit Anti-GDF15/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的生長(zhǎng)分化因子15/巨嗜細(xì)胞抑制因子1抗體
別    名 GDF 15; GDF-15 Growth differentiation factor 15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC 1; MIC-1; MIC1; NAG 1; NAG1; NRG 1; NRG1; NSAID (nonsteroidal anti inflammatory drug) activated protein 1; NSAID; NSAID regulated protein 1; PDF; PLAB; Placental bone morphogenetic protein; Placental bone morphogenic protein; Placental TGF beta; placental transformation growth factor beta; Prostate differentiation factor; PTGF beta; PTGFB; prostate derived factor.   
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 12.5/34kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GDF-15
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.

Subcellular Location:
Secreted.

Tissue Specificity:
Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney.

Similarity:
Belongs to the TGF-beta family.

Database links:

Entrez Gene: 9518 Human

Entrez Gene: 23886 Mouse

Entrez Gene: 29455 Rat

Omim: 605312 Human

SwissProt: Q99988 Human

SwissProt: Q9Z0J7 Mouse

SwissProt: Q9Z0J6 Rat

Unigene: 616962 Human

Unigene: 31325 Mouse

Unigene: 44228 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生長(zhǎng)分化因子15(GDF15)是骨形態(tài)發(fā)生蛋白(BMP)和轉(zhuǎn)化生長(zhǎng)因子-β超家族成員。GDF-15又叫巨噬細(xì)胞抑制因子(macrophage inhibiting cytokine,MIC)-1、胎盤轉(zhuǎn)化生長(zhǎng)因子 (placental transformation growth factor,PTGF)-β、前列腺衍生因子(prostate derived factor,PDF)和胎盤骨形態(tài)發(fā)生蛋白(placental bone morphogeneticprotein,PLAB)。
有學(xué)者認(rèn)為:GDF-15在腫瘤發(fā)展的不同階段發(fā)揮著不同的生物學(xué)作用;隨著腫瘤的發(fā)生發(fā)展,GDF-15可能表達(dá)不同形式的蛋白,在腫瘤發(fā)生的早期階段可能發(fā)揮抑瘤作用,而在腫瘤發(fā)展的后期階段發(fā)揮促瘤作用。
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