日日操日日操,亚洲日本午夜激情,人妻内射精品一区二区,国产一区北条麻妃

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
三线美女在线观看网站,精品 码产区二区,一级看片官网
Rabbit Anti-CHRDL2/PE-Cy3 Conjugated antibody (bs-3860R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3860R-PE-Cy3
英文名稱 Rabbit Anti-CHRDL2/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的乳腺腫瘤新因子1抗體
別    名 BNF1; Breast tumor novel factor 1; CHL2; chordin like 2; Chordin like protein 2 precursor; Chordin related protein 2; CRDL2_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  生長因子和激素  血管內(nèi)皮細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Cow, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CHRDL2 C-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. A member of the chordin family of proteins, it contains a signal peptide and three CR (cysteine-rich repeat) domains. When expressed as a recombinant protein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors.

Function:
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.

Subunit:
Interacts with GDF5 (By similarity). May interact with BMP2, BMP4, BMP5, BMP6, BMP7 and INHBA.

Subcellular Location:
Isoform 1: Secreted (Potential).
Isoform 2: Secreted (Potential).
Isoform 3: Cytoplasm (Potential).
Isoform 4: Cytoplasm (Potential).
Isoform 5: Cytoplasm (Potential).

Tissue Specificity:
Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma.

Post-translational modifications:
Phosphorylation sites are present in the extracellular medium. Isoform 2 is phosphorylated on Ser-402.

Similarity:
Contains 3 VWFC domains.

Database links:

Entrez Gene: 25884 Human

Omim: 613127 Human

SwissProt: Q6WN34 Human

Unigene: 432379 Human

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CHRDL2原來主要用于乳腺癌的研究,近年來研究發(fā)現(xiàn)在腫瘤中也有發(fā)現(xiàn),目前在肺癌,結(jié)腸腫瘤的研究中應(yīng)用較多。
版權(quán)所有 2004-2026 m.bklrv.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
亚热色爱视频| 一区二区三区四区女人| 一级性生活片久久 - 百度| 人妻精品丰满熬妇区| JULIA无码中文一二三区| 99狠狠久久综合| 国产 日韩 欧美 视频 在线| 夜夜草 一区| 亚洲国产天堂在线| 午夜骚逼视频网站| 妖精视频黄色美女视频软件网站| 国产精品与日韩精品| 日韩亚洲色欲在线播放_360影视| 日本熟妇淫荡网| CaoPorn超碰葡京| 欧美区日韩区一区二区三区四区五区| 91插美女| 曰韩一绥黄片| 无码久久国产妻中文| 日韩美女电影一区| 911韩国国产精品视频| 亚洲美熟女综合| 肛交伊人视频| 国产操B大片| 少妇白浆一区二区按摩| 香蕉视频一二区| 日本久久一区色| 国产一区二区三区欧美日韩软件| 男人在线天堂观看| 中文字幕一区二区欧美电影| 欧美精品无毛区| 婷婷丁香五月综合精品| 日韩少妇内射免费播放| 成年九九九十八禁视频| 成人福利亚洲在线| 1024久久毛片免费| 色欲亚洲一区日韩精品| 99在线视频播放| 九九在线黄色片,| 手机大香蕉免费播放器| 黄的视频网站|