日日操日日操,亚洲日本午夜激情,人妻内射精品一区二区,国产一区北条麻妃

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美操逼视屏A,我要看北京一级一级黄片,国产孩交老少交网址
Rabbit Anti-CHRDL2/BF647 Conjugated antibody (bs-3860R-BF647)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3860R-BF647
英文名稱 Rabbit Anti-CHRDL2/BF647 Conjugated antibody
中文名稱 BF647標(biāo)記的乳腺腫瘤新因子1抗體
別    名 BNF1; Breast tumor novel factor 1; CHL2; chordin like 2; Chordin like protein 2 precursor; Chordin related protein 2; CRDL2_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  生長因子和激素  血管內(nèi)皮細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Cow, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CHRDL2 C-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. A member of the chordin family of proteins, it contains a signal peptide and three CR (cysteine-rich repeat) domains. When expressed as a recombinant protein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors.

Function:
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.

Subunit:
Interacts with GDF5 (By similarity). May interact with BMP2, BMP4, BMP5, BMP6, BMP7 and INHBA.

Subcellular Location:
Isoform 1: Secreted (Potential).
Isoform 2: Secreted (Potential).
Isoform 3: Cytoplasm (Potential).
Isoform 4: Cytoplasm (Potential).
Isoform 5: Cytoplasm (Potential).

Tissue Specificity:
Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma.

Post-translational modifications:
Phosphorylation sites are present in the extracellular medium. Isoform 2 is phosphorylated on Ser-402.

Similarity:
Contains 3 VWFC domains.

Database links:

Entrez Gene: 25884 Human

Omim: 613127 Human

SwissProt: Q6WN34 Human

Unigene: 432379 Human

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CHRDL2原來主要用于乳腺癌的研究,近年來研究發(fā)現(xiàn)在腫瘤中也有發(fā)現(xiàn),目前在肺癌,結(jié)腸腫瘤的研究中應(yīng)用較多。
版權(quán)所有 2004-2026 m.bklrv.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
亚台湾\\精品二区| 欧美日韩中文字母专区| 欧美独立网站2区| 欧美精品一区二区三区.COM| 欧美呦日韩呦国产呦| av汤姆在线| 日本一区二区三区10| 天天干美女天天操美女| 伊人福利午夜网| 色婷婷亚洲基地| 成人免费日韩AV午夜福利| 久久久久久久久久一级黄色片美女| 亚洲美女高潮 久久久久久久久| 日本真人视频一区二区三区| 又大又长又粗黄视频| 亚洲国产日韩欧洲| 国产一区后入| 一级黄片大黑屌干亚裔| 岛国日B视频| 午夜激情网站视频免费观看| 日韩欧美人妻一| 亚洲AV成人无码| 久久精品婷婷少妇伊人| AAABBB无遮挡不卡美片免费看| 国产一区 二区 三区四区视频| 淫色av一区二区三区四区在线| 最近中文字幕完整视频高清1| 第一次带白嫩人妻3p在线视频| 日韩免费黄色电影网站| 一区二区三区久久久无缘无故| 又深又粗又爽又猛的视频| 国产精品99午夜视频| 又粗又长又猛又硬的黄片| 激情影院国产久久| 1欧美网站国产| 美国99黄色| 免费國产熟女视频| 欧美黄片久久久久久| 精品一区二区三区桃源| 老熟女免费国产| 天天猛天天干天天爽|