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Rabbit Anti-FAM3B/Gold Conjugated antibody (bs-0711R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0711R-Gold
英文名稱 Rabbit Anti-FAM3B/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的胰腺衍生因子抗體
別    名 C21orf11; PANDER; Cytokine like protein 2 21; PRED44; PANcreatic DERived factor; Protein FAM3B; Protein FAM3B precursor; Family with sequence similarity 3, member B isoform a; FAM3B_MOUSE.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 免疫學(xué)  細(xì)胞凋亡  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FAM3B
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
FAM3B has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner. [Subcellular Location] Secreted. Note=Localized in discrete vesicular and perinuclear structure. Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. Belongs to the FAM3 family.

Function:
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.

Subcellular Location:
Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.

Tissue Specificity:
Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.

Post-translational modifications:
2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.
O-glycosylated.

Similarity:
Belongs to the FAM3 family.

Database links:

Entrez Gene: 54097 Human

Entrez Gene: 52793 Mouse

Omim: 608617 Human

SwissProt: P58499 Human

SwissProt: Q9D309 Mouse

Unigene: 473877 Human

Unigene: 670704 Human

Unigene: 327932 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胰腺衍生因子(PANcreatic DERived fa*ctor,PANDER)是新發(fā)現(xiàn)的一種新型的胰島細(xì)胞因子、由胰島α細(xì)胞和β細(xì)胞分泌的一種分泌型細(xì)胞因子,與β細(xì)胞凋亡密切相關(guān) ,可以誘導(dǎo)胰島素分泌β細(xì)胞,主要用于糖尿病的研究。
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