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Rabbit Anti-MTTP/PE Conjugated antibody (bs-5083R-PE)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5083R-PE
英文名稱 Rabbit Anti-MTTP/PE Conjugated antibody
中文名稱 PE標(biāo)記的微粒體甘油三酯轉(zhuǎn)運(yùn)蛋白
別    名 ABL; Microsomal triglyceride transfer protein (large polypeptide 88kDa); Microsomal triglyceride transfer protein 88kD; Microsomal triglyceride transfer protein; Microsomal triglyceride transfer protein large subunit; MTP; MTP large subunit; MTP_HUMAN; MTTP; Transfer RNA, mitochondrial, proline; tRNA-Pro, mitochondrial; Microsomal triglyceride transfer protein large; Microsomal triglyceride transfer protein large Precursor; microsomal triglyceride transfer protein large subunit precursor.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  脂蛋白  新陳代謝  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Guinea Pig, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 97kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MTTP
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
MTTP catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. MTTP is required for the secretion of plasma lipoproteins that contain apolipoprotein B. It is positively regulated by cholesterol and negatively regulated by insulin. Defects in MTP are the cause of abetalipoproteinemia.

Function:
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.

Subunit:
Heterodimer composed of MTTP and of protein disulfide isomerase (P4HB/PDI) (By similarity).

Subcellular Location:
Endoplasmic reticulum.

Tissue Specificity:
Liver and small intestine. Also found in ovary, testis and kidney.

DISEASE:
Abetalipoproteinemia (ABL) [MIM:200100]: An autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing lipoproteins (chylomicrons, VLDL, LDL, lipoprotein(A)). Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 1 vitellogenin domain.

Database links:

Entrez Gene: 487873 Dog

Entrez Gene: 100734244 Guinea pig

Entrez Gene: 100053803, Horse

Entrez Gene: 4547 Human

Entrez Gene: 17777 Mouse

Entrez Gene: 397381 Pig

Entrez Gene: 100341961 Rabbit

Entrez Gene: 310900 Rat

Omim: 590075 Human

SwissProt: P55156 Cow

SwissProt: P55157 Human

SwissProt: O08601 Mouse

SwissProt: Q865F1 Pig

Unigene: 195799 Human

Unigene: 2941 Mouse

Unigene: 81556 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

微粒體甘油三酯轉(zhuǎn)移蛋白(microsomal triglyceride transfer protein,MTP)是一種主要分布于肝細(xì)胞、腸上皮細(xì)胞中的脂質(zhì)轉(zhuǎn)移蛋白,存在于細(xì)胞微粒體、內(nèi)質(zhì)網(wǎng)腔內(nèi),在內(nèi)質(zhì)網(wǎng)內(nèi)含量最高,占總蛋白的0.5%-1.0%,MTTP在甘油三酯轉(zhuǎn)運(yùn)及極低密度脂蛋白組裝和分泌中發(fā)揮著重要作用。
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