日日操日日操,亚洲日本午夜激情,人妻内射精品一区二区,国产一区北条麻妃

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
91久久精品www人人爽人人做,国产理论片久久午夜精品
Rabbit Anti-IRS1/BF647 Conjugated antibody (bs-0172R-BF647)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0172R-BF647
英文名稱 Rabbit Anti-IRS1/BF647 Conjugated antibody
中文名稱 BF647標(biāo)記的胰島素受體底物-1抗體
別    名 HIRS 1; HIRS1; Insulin Receptor Substrate 1; IRS-1; IRS 1; IRS1; OTTHUMP00000164234; IRS1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  糖尿病  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig,  (predicted: Chicken, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 137kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat IRS-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.

Function:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Subunit:
Interacts with UBTF and PIK3CA. Interacts (via phosphorylated YXXM motifs) with PIK3R1. Interacts with ROCK1 and FER. Interacts (via PH domain) with PHIP. Interacts with GRB2. Interacts with SOCS7. Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif). Interacts with ALK.

Subcellular Location:
IRS1 is predominantly found in the cytoplasm. Nuclear localization may occur in some cell types and under specific stimuli.

Post-translational modifications:
Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding.

DISEASE:
Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM)

Similarity:
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

Database links:

Entrez Gene: 3667 Human

Entrez Gene: 16367 Mouse

Entrez Gene: 25467 Rat

Omim: 147545 Human

SwissProt: P35568 Human

SwissProt: P35569 Mouse

SwissProt: P35570 Rat

Unigene: 471508 Human

Unigene: 4952 Mouse

Unigene: 10476 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信號(hào)傳導(dǎo)(Signaling Intermediates)
胰島素受體底物-1是細(xì)胞中分子量為165-185kDa的磷蛋白,胰島素受體的內(nèi)源性底物。經(jīng)胰島素刺激后其酪氨酸殘基被磷酸化。
版權(quán)所有 2004-2026 m.bklrv.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲av网站在线观看| 粉嫩精品国产色综合久| 狠狠婷婷另类| 色女人视频成人平台| 久久超碰| 色悠悠视频播放| 97人妻夜夜爽二区| 日91熟女| 久久综合黄色片| 久久99热色密臀| 日韩操屁眼视频男女| 日韩精品人妻色欲网| 射精日韩| 老司机精品一区二区| 三级日韩影视福利| 人妻手机在线视频| 日韩123区不卡高清成人电影| 蜜臀92av在线观看| 99久久无码国产精品性出奶 | 国产暴力强伦轩一区二区三区二区| 免费怡人五月天网| 亚洲欧美一区二区偷拍| 午夜3P小视频| 92人妻在线视频| 亚洲avy| 午夜影院黄扣| 老师黑丝av在线| 日韩性av| 性AV一级网站| 欧美夫妻性生活91Av| 无码中文字幕久久久专区| 成人午夜福利100| 欧美一级久久久网址| 久久ww。。。| 亚洲欧洲图片一区二区| ww欧美在线日韩| 精品一二三区久久AAA片| 亚洲日韩A级免费视频黑人| 国产AV亚洲AV| 色五月av中文字幕| 亚区成人免费视频小黄书|