| 產(chǎn)品編號(hào) |
bs-6905R-Bio |
| 英文名稱 |
Rabbit Anti-CDCREL/Biotin Conjugated antibody
|
| 中文名稱 |
生物素標(biāo)記的細(xì)胞周期調(diào)控相關(guān)蛋白1 |
| 別 名 |
5 Sep; CDCrel 1; CDCREL; CDCrel-1; CDCREL1; Cell division control related protein 1; Cell division control-related protein 1; H5 antibody HCDCREL 1; Peanut like 1; Peanut like 1 homolog; Peanut like protein 1; Peanut-like protein 1; Platelet glycoprotein Ib beta chain; PNUTL1; SEPT5; SEPT-5; SEPT 5; SEPT5_HUMAN; Septin 5; Septin5; Septin-5. |
| 規(guī)格價(jià)格 |
100ul/2980元
購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
細(xì)胞生物 免疫學(xué) 細(xì)胞周期蛋白 細(xì)胞分化 細(xì)胞骨架 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Human,
(predicted: Mouse, Rat, Dog, Pig, Cow, Horse, )
|
| 產(chǎn)品應(yīng)用 |
WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
41kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human CDCREL/SEPT5 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010].
Function:
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in platelet secretion.
Subunit:
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2 and SEPT5. In platelets, associated with a complex containing STX4. Interacts with PARK2. This interaction leads to SEPT5 ubiquitination and degradation.
Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha-granules
Tissue Specificity:
Expressed at high levels in the CNS, as well s in heart and platelets (at protein level).
Post-translational modifications:
In platelets, phosphorylated in response to thrombin, phorbol-12-myristate-13-acetate and collagen.
Similarity:
Belongs to the septin family.
Database links:
UniProtKB/Swiss-Prot: Q99719.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SEPTIN(SEPT)家族是細(xì)胞骨架蛋白的一種，具有GTPase的活性。經(jīng)研究發(fā)現(xiàn)，SEPT參與細(xì)胞的分裂、細(xì)胞膜的運(yùn)輸以及構(gòu)成細(xì)胞骨架。SEPTIN5又稱細(xì)胞骨架蛋白SEPT5。
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