| 產(chǎn)品編號 | bs-0828R-PE |
| 英文名稱 | Rabbit Anti-Thrombin receptor/ PAR1/PE Conjugated antibody |
| 中文名稱 | PE標記的蛋白酶激活受體-1抗體 |
| 別 名 | SAR; BXR; Proteinase-activated receptor 1 precursor; Thrombin receptor; Coagulation factor II receptor; D15S227E; Prader-Willi/Angelman region-1; PAR1; Coagulation factor II receptor; CF2R; Coagulation factor II (thrombin) receptor; F2R; HTR; PAR 1; PAR1; Protease activated receptor 1; Proteinase activated receptor 1; Thrombin receptor; TR; PAR-1; Coagulation factor II receptor; Coagulation factor II receptor; PAR-1; PAR1_HUMAN; Proteinase activated receptor 1; Proteinase-activated receptor 1. |
 |
Journal
PMID
IF
Application
[IF=3.332] Kumar M et al. Neuroprotective Effects of Activated Protein C Involve the PARP/AIF Pathway against Oxygen-Glucose Deprivation in SH-SY5Y CellsBrain Sci.2020 Dec 10;10(12):959. FCM、WB ; Human.
|
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領域 | 腫瘤 細胞生物 信號轉導 激酶和磷酸酶 細胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, |
| 產(chǎn)品應用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PAR1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008] Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Platelets and vascular endothelial cells. Post-translational modifications: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 2149 Human Omim: 187930 Human SwissProt: P56488 Baboon SwissProt: P25116 Human Unigene: 482562 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PAR蛋白全稱為蛋白酶體活化受體(Protease-activated receptors)，又稱：凝血酶受體(Thrombin Receptor)是獨立家族的G蛋白偶聯(lián)受體， 研究認為與炎癥，實體腫瘤等密切相關。 PAR1蛋白是乳腺癌細胞侵潤和遷移的必需因子，它是作為基質金屬蛋白酶體1（MMP-1）的受體關鍵性作用，這一研究結果為研制新的抗癌藥物提供新的靶點。 |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
