日日操日日操,亚洲日本午夜激情,人妻内射精品一区二区,国产一区北条麻妃

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产专区HD,国产日韩无码无卡一区二区,高清不卡码视频
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-PPP4C/BF488 Conjugated antibody (bs-0490R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0490R-BF488
英文名稱 Rabbit Anti-PPP4C/BF488 Conjugated antibody
中文名稱 BF488標記的磷酸酯酶-2Ac抗體
別    名 protein phosphatase 4/c; PP4/C; Ser/Thr-protein phosphatase 4 catalitic subunit; serine/threonine-protein phosphatase 4 catalytic subunit isoform X2; PP4C; PP4; PP X; PP-X; PP2AC; PPP4C; PP4; PP4C; PPH3; PPP4; PPX; PP2Ac; PP4C; PP4C_HUMAN; protein phosphatase 4 (formerly X), catalytic subunit; Protein phosphatase 4 catalytic subunit; Protein phosphatase X; protein phosphatase X, catalytic subunit; Serine/threonine protein phosphatase 4 catalytic subunit; Serine/threonine-protein phosphatase-4 catalytic subunit.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經(jīng)生物學  信號轉(zhuǎn)導  細胞凋亡  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Chicken, Dog, Rabbit, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PP4C
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Protein phosphatase 4C consists of a catalytic subunit PPP4C and a regulatory subunit. PPP4R1 and belongs to the PPP phosphatase family, PP X subfamily. Protein phosphatases are involved in determining the phosphorylation state of many regulatory proteins. PPP4C is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.

Function:
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Subunit:
Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 AND GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3.

Subcellular Location:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Similarity:
Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Database links:

Entrez Gene: 5531 Human

Entrez Gene: 56420 Mouse

Entrez Gene: 100009163 Rabbit

Entrez Gene: 171366 Rat

Omim: 602035 Human

SwissProt: P60510 Human

SwissProt: P97470 Mouse

SwissProt: P11084 Rabbit

SwissProt: Q5BJ92 Rat

Unigene: 534338 Human

Unigene: 41998 Mouse

Unigene: 9173 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

激酶和磷酸酶(Kinases and Phosphatases)
蛋白磷酸酶-4(又稱PP4或PPX)是蛋白磷酸酶2A(PP2A)家族的重要成員之一;
PP-2Ac參與細胞周期,生長和分化及多細胞信號通路的調(diào)節(jié),也用于腫瘤方面的研究。
版權(quán)所有 2004-2026 m.bklrv.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
久久久久久少妇| 欧不卡美一区二区| 大香焦伊人AV伊人| 精品免费妓女卖婬全部视频| 老司机 一区二区| 国产亚洲欧美精品91| 成人永久网址| Av播放一区二区三区| 美女做推油操逼视频| 五月天婷婷玖玖电影网站| av不卡一线国语对白字幕| 麻豆优选在线播放| 日韩精品欧美中文字幕| 撕破白丝后操水晶白丝美女| 天天综合永久入口| 亚洲中文字幕日产无码久久| 亚洲日韩无一区二区三区| 欧美一道高清一区二区三区| 丝袜腿一区二区日本| 国产99中文字幕| 国产精品视频免费一区二区三区| 亚洲精品国产一区二区三区| av中文五月天| 91视频靠逼| 欧美 日韩 精品 午夜| 久久久久久久久久玛| 黄片一级日韩欧美| 日韩视频在线观看专区不卡| 国产午夜人妻精品影院 | 久久色 婷婷| 日本美女在线高潮精品| 免费欧美a区| 欧美韩一起草网站| 成人精品乱码| 久操亚洲天堂| 日本久久精品。| 黄色片麻豆2028| 美女无内视频网站免费| 国产无码精品视| 中文字幕精品久久久久久久影院| 淫中文字幕麻豆|