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Rabbit Anti-phospho-CTNNA1 (Ser641)/HRP Conjugated antibody (bs-5280R-HRP)
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5280R-HRP
英文名稱 Rabbit Anti-phospho-CTNNA1 (Ser641)/HRP Conjugated antibody
中文名稱 辣根過(guò)氧化物酶標(biāo)記的磷酸化α-連環(huán)蛋白抗體
別    名 p-CTNNA1 (Ser641); CTNNA1 (phospho-Ser641); CTNNA1 (phospho-S641); alpha 1 Catenin (phospho S641); alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadherin associated protein; CAP 102; CAP102; Catenin (cadherin associated protein) alpha 1 102kDa; Catenin alpha 1; CTNNA 1; CTNNA1; Alpha-cats; FLJ36832; NY REN 13 antigen; CTNA1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞粘附分子  細(xì)胞骨架  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 100kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human CTNNA1 around the phosphorylation site of Ser641 [DD(p-S)DF]
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.

Function:
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Subunit:
Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin. Binds MLLT4 and F-actin. Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and beta-catenin/CTNNB1 or gamma-catenin/JUP; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interacts with ARHGAP21 and with AJUBA. Interacts with LIMA1.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.

Tissue Specificity:
Expressed ubiquitously in normal tissues.

Post-translational modifications:
Sumoylated.

Similarity:
Belongs to the vinculin/alpha-catenin family.

Database links:

Entrez Gene: 1495 Human

Entrez Gene: 12385 Mouse

Entrez Gene: 307505 Rat

Omim: 116805 Human

SwissProt: P35221 Human

SwissProt: P26231 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

α-catenin是一種多功能的蛋白質(zhì),能鏈接E-\N-\P-鈣粘附分子,具有參與細(xì)胞粘附和介導(dǎo)信號(hào)轉(zhuǎn)導(dǎo)的雙重功能,并與腫瘤的發(fā)生發(fā)展及浸潤(rùn)密切相關(guān)。 在正常個(gè)體中,βα-catenin和鈣黏蛋白形成復(fù)合體,介導(dǎo)同型細(xì)胞的粘附,維持細(xì)胞的穩(wěn)定;同時(shí),α-catenin作為Wnt/α-catenin信號(hào)通路的關(guān)鍵成員在介導(dǎo)信號(hào)轉(zhuǎn)導(dǎo)過(guò)程中調(diào)控細(xì)胞的增殖和凋亡。 在惡性腫瘤中,α-catenin的表達(dá)呈現(xiàn)明顯的異質(zhì)性,促使細(xì)胞異常增殖,還可使細(xì)胞之間的黏附性減弱,侵襲性增強(qiáng)。
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