日日操日日操,亚洲日本午夜激情,人妻内射精品一区二区,国产一区北条麻妃

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
91人妻一区二在线,超碰在选欧美成人,熟女一区五区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-ITGB3 (Tyr785)/PE-Cy5 Conjugated antibody (bs-5452R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5452R-PE-Cy5
英文名稱 Rabbit Anti-phospho-ITGB3 (Tyr785)/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的磷酸化整合素β3抗體
別    名 Integrin beta 3 (phospho Y785); p-Integrin beta 3 (phospho Y785); Integrin beta chain, β3 precursor; Integrin Beta 3; CD 61; CD61; CD61 antigen; GP3A; GPIIIa; HPA 1; HPA 4; Integrin beta 3 (platelet glycoprotein IIIa antigen CD61); Integrin beta chain beta 3; ITG B3; ITGB 3; ITGB3; NAIT; Platelet fibrinogen receptor beta subunit; Platelet glycoprotein IIIa; platelet glycoprotein IIIa precursor; Platelet membrane glycoprotein IIIa; PTP.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 免疫學  干細胞  轉錄調節(jié)因子  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 87kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human ITGB3 around the phosphorylation site of Tyr785
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The ITGB3 (Integrin beta chain beta 3) protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

Function:
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Subunit:
Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with HIV-1 Tat. Interacts with PDIA6 following platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with MYO10.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Post-translational modifications:
Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.

DISEASE:
Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.

Similarity:
Belongs to the integrin beta chain family. Contains 1 VWFA domain.

Database links:

Entrez Gene: 3690 Human

Entrez Gene: 16416 Mouse

Omim: 173470 Human

SwissProt: P05106 Human

SwissProt: O54890 Mouse

Unigene: 218040 Human

Unigene: 87150 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD61抗原又稱為GP III a,是一種表達于血小板、巨核細胞、單核細胞、巨噬細胞和內皮細胞上的糖蛋白。CD61和CD41構成血小板糖蛋白II b/III b。
版權所有 2004-2026 m.bklrv.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
海外三级网| 亚洲超清无码视频| 嗯,嗯,嗯嗯嗯好爽视频| 飞看亚洲美女高潮好| 永久黄色电影| 国产精品伦理影视大全| 欧差一二三区| 日韩伦理在线视频中文字幕| 亚洲成a人| 日韩无码i一区二区三区| caoporn个人免费| 日韩久久黄页抽插无码| 美女国产喷水在线| 亚洲性图欧美色图第3页| 蜜臀av性久久久久蜜臀aⅴ浪潮 | 人妻在线免费视频JAVA| 99丰满人妇一区二区三区| 伊人春色婷婷色色| 国产欧美一区日韩| 又大又长又黄又粗又色| 女同h| 亚洲欧美日韩乱色| 国产精品成久久久| 欧美 国产 在线 一区| 免费黄色呦呦网站视频入口| 日本高清国产精品| 大相煮国产视频精品久久| 国产又大又长又粗又黄| 色一区综合网| 91精品国产高清一区二区三密臀| av无码综合| 欧美日本国产在线一区二区三区| 久久福利五月天| 美女淫乱视频网站| 生活片1区2区3区4区| 成人h在线观看| 五月社区婷婷无码| Av不卡中文一二三区| 少妇日本插| 久久精品无码不卡Av| 成人电影精品|