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Rabbit Anti-Exendin 4/BF647 Conjugated antibody (bs-4121R-BF647)
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-4121R-BF647
英文名稱 Rabbit Anti-Exendin 4/BF647 Conjugated antibody
中文名稱 BF647標(biāo)記的GLP1類似蛋白Exendin4抗體
別    名 Exendin 4; Exendin4; Exendin-4; EXE4_HELSU .  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  神經(jīng)生物學(xué)  糖尿病  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 4.3kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Gila monster lizard Exendin 4
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Exendin 4 is a 39 amino acid peptide found in venom from the Gila monster Helicoderma suspectum. It is a member of the glucagon secretin family of peptide hormones and neuropeptides. Exendin 4 is a potent agonist of the GLP1 receptor and hence a potent stimulator of insulin secretion.

Function:
Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed by the venom gland.

Similarity:
Belongs to the glucagon family.

Database links:
UniProtKB/Swiss-Prot: P26349.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Exendin-4是從希拉毒蜥唾液中分離的一種多肽激素,由39個(gè)氨基酸殘基組成,與胰高血糖素樣肽1(GLP-1)有53%的同源性。Exendin-4具有高度的組織特異性,僅在希拉毒蜥的唾液腺中表達(dá), 具有促進(jìn)葡萄糖依賴性的胰島素分泌、促進(jìn)β細(xì)胞增殖、減慢胃排空、抑制食物攝取和減輕體重等作用。
腸促胰島素類似物(exendin-4,Ex-4)是從美洲一種毒蜥的唾液中分泌的胰升糖素樣肽-1(glucagon-like peptide-1,GLP-1)類似物,它具有促進(jìn)胰腺胰島素的分泌、增加胰島素敏感性及改善胰島細(xì)胞功能的作用,且不被二肽基肽酶Ⅳ(DPP-Ⅳ)分解,血漿半衰期較長(zhǎng),因而在人類,對(duì)糖尿病治療應(yīng)用來(lái)說(shuō)是穩(wěn)定、長(zhǎng)效的有治療前景的藥物。
鈍尾毒蜥 (Gila monster)
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